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Kidney Week

Abstract: INFO32

Prevention of Urinary Stones with Hydration (PUSH): A Urinary Stone Disease Research Network Trial

Session Information

  • Informational Posters
    October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category:

  • No subcategory defined

Authors

  • Scales, Charles D., Duke University, Durham, North Carolina, United States
  • Al-khalidi, Hussein, Duke University, Durham, North Carolina, United States
  • Desai, Alana C., Washington University in St. Louis, Saint Louis, Missouri, United States
  • Harper, Jonathan D., University of Washington, Seattle, Washington, United States
  • Lai, Henry, Washington University School of Medicine, St Louis, Missouri, United States
  • Maalouf, Naim M., University of Texas Southwestern Medical Center, Dallas, Texas, United States
  • Reese, Peter P., University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Tasian, Gregory Edward, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
  • Kirkali, Ziya, NIDDK / NIH, Bethesda, Maryland, United States
  • Wessells, Hunter, University of Washington, Seattle, Washington, United States

Group or Team Name

  • Urinary Stone Disease Research Network
Description

The Urinary Stone Disease Research Network (USDRN) was established by the NIDDK to address high-impact questions in urinary stone disease. The goals of the USDRN are to 1) provide evidence on the effects of fluid intake on recurrent stone disease, 2) understand and mitigate the burden of pain and suffering from ureteral stents, and 3) create a data and biospecimen resource for future research. The network comprises 4 Clinical Centers: University of Pennsylvania/Children’s Hospital of Philadelphia, University of Texas Southwestern Medical Center, University of Washington, and Washington University in St. Louis, along with the USDRN Scientific Data and Research Center based at the Duke Clinical Research Institute.
The PUSH Study is a randomized clinical trial of a multi-component program of behavioral interventions to increase fluid intake adherence, monitored using a smart water bottle. Adults and adolescents aged ≧12 years with a symptomatic renal or ureteral stone within the past 3 years and low urine volume are eligible. Exclusion criteria include infectious or monogenic causes of stone disease, comorbid conditions that preclude increased fluid intake, and vulnerable populations. Participants randomized to the intervention arm receive an adaptive program of behavioral interventions, beginning with financial incentives, along with Structured Problem Solving and other automated adherence interventions (Figure). The primary endpoint is recurrence of a symptomatic stone at 2 years, resulting in a target sample size of 1642 participants. Secondary endpoints include changes in radiographic stone burden, 24 hour urine output, and urinary symptoms. Recruitment is ongoing at the Clinical Centers, with opportunities for enrollment from remote sites.

Figure. PUSH Study Overview

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases