Kidney Week

Abstract: TH-PO1123

Optimising Renal Perfusion Measurement with Arterial Spin Labelling

Session Information

• CKD: Clinical, Outcomes, Trials - I
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 1902 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

• Gillis, Keith, University of Glasgow, Glasgow, United Kingdom

Keith Gillis,

• Rankin, Alastair J., University of Glasgow, Glasgow, United Kingdom

Alastair J. Rankin,

• Allwood-Spiers, Sarah, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom

Sarah Allwood-Spiers,

• Radjenovic, Aleksandra, University of Glasgow, Glasgow, United Kingdom

Aleksandra Radjenovic,

• Roditi, Giles, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom

Giles Roditi,

• Patel, Rajan, University of Glasgow, Glasgow, United Kingdom

Rajan Patel,

• Mark, Patrick B., University of Glasgow, Glasgow, United Kingdom

Patrick B. Mark,

Group or Team Name

• Glasgow Renal Research Group

Background

Arterial spin labelling is a magnetic resonance imaging technique, allowing measurement of renal perfusion without a contrast agent. The optimal manner of image analysis is not known, and we sought to determine which ASL measurement correlates with measured glomerular filtration rate (GFR).

Methods

Healthy volunteers underwent measurement of glomerular filtration rate (GFR) by technetium-99m dimercaptosuccinic acid (DMSA) renography; CKD-EPI eGFR was calculated from serum creatinine. Renal anatomy was evaluated on HASTE imaging whilst ASL was performed using flow sensitive alternating inversion recovery (FAIR) labelling and true fast imaging with steady state precession (True-FISP) acquisition. Perfusion was measured in regions of interest in cortex and whole kidney. The perfusion of each kidney was calculated as a factor of renal volume and whole kidney perfusion, whilst total kidney perfusion was the sum of right and left kidney perfusion.

Results

12 healthy volunteers were recruited with an age of 50.8±13.7 years, and eGFR of 100.9±13.3 ml/min/1.73m², DMSA GFR was 97.3±23.4 ml/min/1.73m², mean cortical perfusion was 259.3±56 ml/min/100g, mean whole kidney perfusion was 215.6±35.4 ml/min/100g, and total kidney perfusion was 766.5±186.5 ml/min. In an analysis of 24 kidneys, there was significant correlation between single kidney GFR and kidney perfusion (r=0.6, p=0.0018) but not cortical (r=-0.041, p=0.85) or whole kidney perfusion (r=0.091, p =0.67). In an analysis of each individual, there was significant correlation of total GFR with total kidney perfusion (r=0.71, p=0.01).

Conclusion

Assessment of renal physiology using ASL MRI may be best expressed by measurement of total renal perfusion.