ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: FR-PO1099

Lupus Nephritis (LN) Patients with Crescentic Proliferative Lesions Show Lower IgG Glomerular Staining

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Moraes, André L., Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
  • Aguirre, Marcela T., Hospital das Clinicas FM USP Sao Paulo, CUENCA, Ecuador
  • Jorge, Lectícia, University of São Paulo, São Paulo, Brazil
  • Dias, Cristiane B., University of Sao Paulo, Brazil, São Paulo, Brazil
  • Woronik, Viktoria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Group or Team Name

  • Nephrology Division
Background

Literature is scarce in describing outcomes and histological associations of LN patients with crescents. The immunofluorescence findings may suggest the pathophysiology of lesions and therefore have implications in the clinical behavior of LN. Our objective was to evaluate renal outcome and histological associations of patients with proliferative LN with and without crescents.

Methods

In this single-center, retrospective cohort study, 138 eligible LN patients were evaluated. The clinical features at baseline and at the end of follow-up were evaluated. eGFR was calculated using CKD-EPI equation. Kidney biopsies were classified according to the ISN/RPS Classification and immunofluorescence patterns. We performed comparative analyses between groups with different proportions and without crescentic lesions in kidney biopsy. Univariate analysis utilized Chi Squared test (n,%) for count and one-way analysis of variance, followed by Student- Newman Keuls tests for continuous variables.

Results

As shown in the image below.

Conclusion

Patients with crescentic (≥50% crescents) form showed at baseline, lower CKD-EPI (p<0.05), higher activity index (p<0.05) and lower intensity of IgG staining (p<0.05) than patients with no crescents on biopsy. The groups presented no difference in clinical outcomes, however, at the end of follow-up, the crescentic group presented a trend towards a higher proportion of individuals with CKD-EPI under 60ml/min/1.73m2.