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Abstract: FR-PO803

Association of Fruit and Vegetable Intake with All-Cause Mortality in Hemodialysis Patients (DIET-HD): A Prospective Cohort Study

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Saglimbene, Valeria Maria, University of Sydney, Sydney, Australia
  • Wong, Germaine, University of Sydney, Sydney, New South Wales, Australia
  • Ruospo, Marinella, Diaverum, Bari, Italy
  • Palmer, Suetonia, University of Otago, Christchurch, New Zealand
  • Natale, Patrizia, Diaverum, Bari, Italy
  • Teixeira-Pinto, Armando, University of Sydney, Sydney, New South Wales, Australia
  • Carrero, Juan Jesus, Karolinska Institutet, Stockholm, Sweden
  • Stenvinkel, Peter, Karolinska University Hospital Huddinge, Stockholm, Sweden
  • Johnson, David W., Princess Alexandra Hospital, Brisbane, Queensland, Australia
  • Tonelli, Marcello, University of Calgary, Calgary, Alberta, Canada
  • Bernat, Amparo, Diaverum Renal Services, Valencia, Spain
  • Török, Marietta, Diaverum Renal Services, Valencia, Spain
  • Bednarek, Anna, Diaverum Renal Services, Valencia, Spain
  • Timofte, Delia, Diaverum, Bari, Italy
  • Fabricius, Elisabeth, Diaverum, Bari, Italy
  • Stroumza, Paul, Diaverum Renal Services, Valencia, Spain
  • Wollheim, Charlotta, Diaverum Healthcare Services, Malmoe, Sweden
  • Hegbrant, Jorgen BA, Diaverum Renal Services Group, Lund, Sweden
  • Craig, Jonathan C., University of Sydney/Children's Hospital, Sydney, New South Wales, Australia
  • Strippoli, Giovanni F.M., University of Bari, Bari, Italy

Group or Team Name

  • on behalf of DIET-HD investigators
Background

Higher fruit and vegetable intake is associated with lower vascular and all-cause mortality for the general population. However, whether fruit and vegetable consumption benefits patients treated with haemodialysis is uncertain. We evaluated the association of fruit and vegetable intake with mortality outcomes in adults on hemodialysis.

Methods

The DIET-HD study was a prospective cohort study involving 9757 adults treated with hemodialysis. Fruit and vegetable intake was measured using the GA2LEN food frequency questionnaire. Cox regression analyses adjusted for sociodemographic and clinical variables and clustered by country were conducted.

Results

During a median follow up of 2.7 years (18,666 person-years), there were 2087 deaths, of which 958 were vascular deaths. Overall, higher combined intake of fruit and vegetables was associated with lower risks of non-vascular and all-cause mortality. The risk for vascular mortality was lower with the highest tertile of intake although the 95% confidence interval included the possibility of a null effect. With reference to the lowest tertile of intake (0 to 5.5 servings per week), the adjusted hazards ratios (95% confidence interval) for the middle (5.6 to 10 servings per week) and highest (>10 servings per week) tertiles were 0.88 (0.76-1.02) and 0.77 (0.66-0.91) for non-vascular mortality; 0.90 (0.81-1.00) and 0.80 (0.71-0.91) for all-cause mortality ; and 0.95 (0.81-1.11) and 0.84 (0.70-1.00) for vascular mortality.

Conclusion

Higher consumption of fruit and vegetables is associated with lower risk of mortality in hemodialysis patients.