Kidney Week

Abstract: FR-PO803

Association of Fruit and Vegetable Intake with All-Cause Mortality in Hemodialysis Patients (DIET-HD): A Prospective Cohort Study

Session Information

• Dialysis: Hospitalization and Mortality
  October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Saglimbene, Valeria Maria, University of Sydney, Sydney, Australia

Valeria Maria Saglimbene,

• Wong, Germaine, University of Sydney, Sydney, New South Wales, Australia

Germaine Wong,

• Ruospo, Marinella, Diaverum, Bari, Italy

Marinella Ruospo,

• Palmer, Suetonia, University of Otago, Christchurch, New Zealand

Suetonia Palmer,

• Natale, Patrizia, Diaverum, Bari, Italy

Patrizia Natale,

• Teixeira-Pinto, Armando, University of Sydney, Sydney, New South Wales, Australia

Armando Teixeira-Pinto,

• Carrero, Juan Jesus, Karolinska Institutet, Stockholm, Sweden

Juan Jesus Carrero,

• Stenvinkel, Peter, Karolinska University Hospital Huddinge, Stockholm, Sweden

Peter Stenvinkel,

• Johnson, David W., Princess Alexandra Hospital, Brisbane, Queensland, Australia

David W. Johnson,

• Tonelli, Marcello, University of Calgary, Calgary, Alberta, Canada

Marcello Tonelli,

• Bernat, Amparo, Diaverum Renal Services, Valencia, Spain

Amparo Bernat,

• Török, Marietta, Diaverum Renal Services, Valencia, Spain

Marietta Török,

• Bednarek, Anna, Diaverum Renal Services, Valencia, Spain

Anna Bednarek,

• Timofte, Delia, Diaverum, Bari, Italy

Delia Timofte,

• Fabricius, Elisabeth, Diaverum, Bari, Italy

Elisabeth Fabricius,

• Stroumza, Paul, Diaverum Renal Services, Valencia, Spain

Paul Stroumza,

• Wollheim, Charlotta, Diaverum Healthcare Services, Malmoe, Sweden

Charlotta Wollheim,

• Hegbrant, Jorgen BA, Diaverum Renal Services Group, Lund, Sweden

Jorgen BA Hegbrant,

• Craig, Jonathan C., University of Sydney/Children's Hospital, Sydney, New South Wales, Australia

Jonathan C. Craig,

• Strippoli, Giovanni F.M., University of Bari, Bari, Italy

Giovanni F.M. Strippoli,

Group or Team Name

• on behalf of DIET-HD investigators

Background

Higher fruit and vegetable intake is associated with lower vascular and all-cause mortality for the general population. However, whether fruit and vegetable consumption benefits patients treated with haemodialysis is uncertain. We evaluated the association of fruit and vegetable intake with mortality outcomes in adults on hemodialysis.

Methods

The DIET-HD study was a prospective cohort study involving 9757 adults treated with hemodialysis. Fruit and vegetable intake was measured using the GA²LEN food frequency questionnaire. Cox regression analyses adjusted for sociodemographic and clinical variables and clustered by country were conducted.

Results

During a median follow up of 2.7 years (18,666 person-years), there were 2087 deaths, of which 958 were vascular deaths. Overall, higher combined intake of fruit and vegetables was associated with lower risks of non-vascular and all-cause mortality. The risk for vascular mortality was lower with the highest tertile of intake although the 95% confidence interval included the possibility of a null effect. With reference to the lowest tertile of intake (0 to 5.5 servings per week), the adjusted hazards ratios (95% confidence interval) for the middle (5.6 to 10 servings per week) and highest (>10 servings per week) tertiles were 0.88 (0.76-1.02) and 0.77 (0.66-0.91) for non-vascular mortality; 0.90 (0.81-1.00) and 0.80 (0.71-0.91) for all-cause mortality ; and 0.95 (0.81-1.11) and 0.84 (0.70-1.00) for vascular mortality.

Conclusion

Higher consumption of fruit and vegetables is associated with lower risk of mortality in hemodialysis patients.