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Abstract: TH-PO461

Dialysis Modality and Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis

Session Information

Category: Hypertension and CVD

  • 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

  • Boonpheng, Boonphiphop, East Tennessee State University, Johnson City, Tennessee, United States
  • Thongprayoon, Charat, Bassett Medical Center, Cooperstown, New York, United States
  • Addo-Yobo, Emmanuel, East Tennessee State University, Johnson City, Tennessee, United States
  • Cheungpasitporn, Wisit, University of Mississippi Medical Center, Jackson, Mississippi, United States
Background

Several studies have demonstrated that end- stage renal disease (ESRD) patients on dialysis are at higher risk for atrial fibrillation, which can be associated with stroke and increased mortality. However, the risk of atrial fibrillation in patients on different renal replacement modality remains unclear. We performed this meta-analysis to assess the risks of atrial fibrillation in ESRD patients on hemodialysis (HD) compared to peritoneal dialysis (PD).

Methods

A systematic review was conducted in MEDLINE, EMBASE, Cochrane databases from inception through April 2018 to identify studies that evaluated the risk of atrial fibrillation of patients on different dialysis modalities. Effect estimates from the individual study were extracted and combined using random-effect, generic inverse variance method of DerSimonian and Laird.

Results

5 observational studies with a total of 22,779 dialysis patients (19,623 on HD and 3,156 on PD) were enrolled. Compared with PD, HD was associated with significantly increased risk of atrial fibrillation with pooled rate ratio of 1.46 (95% CI, 1.09-1.95). Meta-regression showed significant negative correlations between risk of AF among HD patients and year of study (slopes = -0.049, P = 0.04).

Conclusion

HD status is associated with 46% higher risk of atrial fibrillation compared to PD. However, compared to those on PD, there are potential reductions in the risk of atrial fibrillation among ESRD patients on HD overtime.