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Abstract: FR-PO218

Evaluation of the Effects of Allopurinol on Metabolic Acidosis in Patients with CKD

Session Information

Category: CKD (Non-Dialysis)

  • 1902 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Author

  • Miri, Maryam, Kidney transplantation complications research center,Mashhad University of Medical Sciences, Mashhad, Iran (the Islamic Republic of)
Background

Chronic kidney disease(CKD) is a disabling disease with multiple complications. Increased serum level of uric acid due to glomerular filtration rate (GFR) impairment is an importance and the lack of a similar study In Iran, this study was designed to evaluate the effect of allopurinol on metabolic acidosis in patients with renal failure.

Methods

In this randomised controlled trial (RCT) study, 50 patientswithCKDstage II-IV, who referred to Ghayem Hospital, were selected and randomly divided into two equal groups of 25 subjects. In addition to standard treatments, the intervention group received 100 mg allopurinol tablet for 3 months and the control group received placebo. Demographic data were obtained from each subject.Serum uric acid level, creatinine, pH blood and bicarbonate levels were obtained at the initiation of treatment and at the end of the third month.

Results

The mean age of subjects was 54.04±12.62 years. The most common cause of CKD was Diabetes Mellitus (36.0%). Allopurinol administration resulted in a significant increase bicarbonate and PH(p<0.001 each) compared to control group. A significant reduction in uric acid (p<0.05) and increase in GFR (p<0.05) was observed in both groups.

Conclusion

Allopurinol may ameliorate metabolic acidosis, glomerular filtration and uric acid in patients with CKD