Kidney Week

Abstract: SA-PO725

Effect of Pentoxifylline on Pericyte in Aging Mice Kidney

Session Information

• Geriatric Nephrology
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Geriatric Nephrology

• 1100 Geriatric Nephrology

Authors

• Kim, Hyung Duk, Seoul St. Mary's hospital, Seoul, Korea (the Republic of)

Hyung Duk Kim,

• Kim, Eun Nim, Division of Nephrology, Department of Internal Medicine, Seoul, Korea (the Republic of)

Eun Nim Kim,

• Lim, Ji Hee, Division of Nephrology, Department of Internal Medicine, Seoul, Korea (the Republic of)

Ji Hee Lim,

• Kim, Min Young, Division of Nephrology, Department of Internal Medicine, Seoul, Korea (the Republic of)

Min Young Kim,

• Yoon, Hye Eun, Incheon St. Mary's Hospital, Incheon, Korea (the Republic of)

Hye Eun Yoon,

• Ko, Eun jeong, Seoul St. Mary's hospital, Seoul, Korea (the Republic of)

Eun jeong Ko,

• Ban, Tae Hyun, Seoul St. Mary's hospital, Seoul, Korea (the Republic of)

Tae Hyun Ban,

• Chung, Byung ha, Seoul St. Mary's hospital, Seoul, Korea (the Republic of)

Byung ha Chung,

• Park, Cheol Whee, Seoul St. Mary's hospital, Seoul, Korea (the Republic of)

Cheol Whee Park,

• Yang, Chul Woo, Seoul St. Mary's hospital, Seoul, Korea (the Republic of)

Chul Woo Yang,

• Kim, Yong-Soo, Seoul St. Mary's hospital, Seoul, Korea (the Republic of)

Yong-Soo Kim,

• Choi, Bumsoon, Seoul St. Mary's hospital, Seoul, Korea (the Republic of)

Bumsoon Choi,

Background

In aging kidney, oxidative stress and inflammation lead to a decrease in renal function. Recent studies related to the aging process of the kidneys have shown that pericyte is a progenitor cell of myofibroblast, and the relationship between renal fibrosis and pericyte has been reported. In this study, we investigated the effect of pentoxifylline on pericyte.

Methods

2, 12, and 24-months-old mice were assigned to control group. (Each group consisted of 7 mice) Seven 18-month-old mice were treated with pentoxifylline for 6 months.
Pericyte was confirmed by PDGFR-beta and NG2 double stain.

Results

Abundant microvascular density was detected in kidney of 2 and 12-months-old young mice. In 24-months-old mice kidney, CD31 stain decreased and collagen I stain increased which means progression of renal fibrosis. In the Pentoxifylline group, the collagen I stain was significantly decreased and the microvascular density was increased compared to the 24 months group. In the 24-months group, the pericyte marker was significantly decreased and the endothelial contact was disappeared. However, the pericyte was not decreased in the pentoxifylline group and maintained their perivascular location.

Conclusion

Pentoxifylline attenuates tubulointerstitial fibrosis in aging mice kidney via pericyte.