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Abstract: TH-PO858

Association Between MYH9 and APOL1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes in a Chinese Han Population

Session Information

Category: Diabetic Kidney Disease

  • 601 Diabetic Kidney Disease: Basic

Authors

  • Zhao, Hailing, China-Japan Friendship Hospital, Beijing, China
  • Li, Ping, China-Japan Friendship Hospital, Beijing, China
Background

Single nucleotide polymorphisms (SNPs) in MYH9-APOL1 gene regions have been reported to be associated with diabetic kidney disease (DKD) in the American population. The susceptibility of MYH9 and APOL1 polymorphisms with DKD in Chinese populations has not been well studied. In this study, we examined the association of MYH9 rs3752462 (T>C) and APOL1 rs136161 (C>G) with DKD in a Chinese Han population.

Methods

MYH9 rs3752462 (T>C) and APOL1 rs136161 (C>G) were genotyped in 303 DKD patients and 364 type 2 diabetes mellitus (T2DM) patients without kidney disease using the TaqMan SNP genotyping assay. Chi-squared test and multivariate logistic regression were used to evaluate the association.

Results

We observed that only MYH9 rs3752462 was associated with DKD (genotype, P= 0.004; allele, P= 0.002). Genetic model analysis revealed that rs3752462 was associated with increased risk of DKD under a dominant model adjusted by age and sex (adjusted Odds ratio [aOR], 1.675; 95% CI 1.225-2.289; P= 0.001) and an additive model (TC vs TT: aOR, 1.649; 95% CI 1.187-2.290; CC vs TT: aOR, 1.817; 95% CI 0.980-3.367; P= 0.005). The combined effect of rs3752462 TC + rs136161 CC genotype showed a association of DKD adjusted by age and sex (aOR, 1.732; 95% CI 1.128-2.660; P= 0.012). After a Holm-Bonferonni correction for multiple tests, the C allele frequencies of the rs3752462 and the TC + CC genotype in dominant model were considered statistically significant with a markedly increased risk of DKD (P<0.00208; P<0.002).

Conclusion

Our results suggest that MYH9 rs3752462 is significantly associated with an increased risk of DKD in Chinese Han individuals.

Funding

  • NIDDK Support