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Abstract: FR-PO1090

A Composite Urinary Biomarkers to Predict Pathological Tubulointerstitial Lesions in Lupus Nephritis

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Tan, Ying, Peking University first hospital, Beijing, China
  • Ding, Ying, Pekin university international hospital, Beijing, China
  • Zhao, Minghui, Reanl division, Peking University First Hospital,, Beijing, China
Background


This study aims to evaluate the clinical value of urinary biomarkers including kidney injury molecule-1 (KIM-1), neutrophil gelatinase–associated lipocalin (NGAL) and monocyte chemoattractant protein 1 (MCP-1) in lupus nephritis.

Methods


A total of 109 biopsy-proven lupus nephritis patients were included, and 50 healthy individuals were collected as the normal controls. The urinary KIM-1, NGAL and MCP-1 levels were measured by ELISA, and the correlations of clinical and histological features with them were further assessed. Receiver operating characteristic curves were performed and cox regression model was applied to identify prognostic factors associated with renal outcomes.

Results

Active lupus nephritis patients exhibited elevated urinary levels of KIM-1, NGAL and MCP-1 in comparison with lupus nephritis patients in remission (P<0.001) and healthy controls (P<0.001). The urinary KIM-1 level was correlated with pathological tubular atrophy (r=0.208, P<0.05) and increased significantly in the presence of interstitial inflammatory lesions (P=0.031). The urinary KIM-1, NGAL and MCP-1 levels were higher in patients with active tubulo-interstitial lesions than those with only chronic lesions (P=0.015, P=0.230 and P=0.086, respectively). A combination of KIM-1, NGAL and MCP-1 was a good indicator for diagnosing active tubulo-interstitial lesions (AUC: 0.796). The combination of KIM-1 and NGAL was identified as an independent risk factor for renal outcomes (HR 7.572, P<0.05).

Conclusion

The urinary KIM-1, NGAL, MCP-1 levels were associated with kidney injury indices in lupus nephritis. The combination of the three biomarkers increased its power in predicting tubulo-interstitial lesions and renal outcomes.

Funding

  • Government Support - Non-U.S.