ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: FR-PO238

Ketosteril Effects on Advanced CKD: Implications from Taiwan Population-Based Study

Session Information

Category: CKD (Non-Dialysis)

  • 1902 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Author

  • Pei-Chun, Fan, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan, Taoyuan, Taiwan
Background

Chronic kidney disease (CKD) is a risk factor for mortality and morbidity. Many clinical studies to investigate whether lowering protein intake with ketoacid analogue (LPD-KA) supplement can attenuate the progression of CKD which were unable to have a definite conclusion. This study aims to evaluate the benefit of LPD-KA in patients with advanced CKD.

Methods

The study analyzed encrypted datasets from Taiwan’s National Health Insurance Research Database. The exposure group was the LPD-KA which fulfilled the medication possession rate > 90% during the first 90 days of follow up and the comparison group was non-users. Outcomes included mortality, dialysis, cardiovascular event, sepsis and blood transfusion at 2-year follow up. Diabetes mellitus (DM) was a stratum variable of interest.

Results

The data of 2654 patients in the LPD-KA group and 5308 propensity score matched patients in the LPD-KA naive group between January 1, 2001 and December 31, 2013 were analyzed. Patients on LPD-KA had lower mortality (8.1% vs. 11.5%; hazard ratio [HR] 0.69, 95% confidence interval [CI] 0.59-0.81) and lower composite cardiovascular events (10.1% vs. 12.5%; HR 0.78, 95% CI 0.68-0.90). When stratifying analyses by DM, LPA-KA had beneficial effects on composite cardiovascular events and dialysis in patients without DM, but not in patients with DM (P for interaction < 0.05). The LPD-KA prolonged the dialysis for a median of 1.8 months (P < 0.001) in the non-DM group, but not in the DM group (0.2 month, P = 0.515).

Conclusion

LPD-KA might be a effective therapy for patient of CKD especially in patients without DM. Cardiovascular and infective event is less in LPD-KA group. Further investigation with earlier treatment to improve the outcome is warranted.