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Abstract: FR-PO667

Factors Associated with Peritoneal Membrane Permeability in Patients Starting Peritoneal Dialysis

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Tseke, Paraskevi, General Hospital "Alexandra", Athens, Greece
  • Andrikos, Emilios, G.Hatzikosta General Hospital , Ioannina, Greece
  • Perrakis, Konstaninos, University Hospital of Hrakleio, University of Crete, Hrakleio, Greece
  • Balafa, Olga, University Hospital , Ioannina, Greece
  • Liakopoulos, Vassilios, AHEPA, University Hospital , Thessaloniki, Greece
  • Melexopoulou, Christine, Laiko Hospital, Ethniko Kapodistriako University, Athens, Greece
  • Katsinas, Chrhstos, "Bodosakio" General Hospital , Ptolemaida, Greece
  • Margellos, Vasileios, "Ant. Mpilis" Nephrology Department Evaggelismos Hospital, Athens, Greece
  • Theodoridis, Marios, Univesity Hospital of Alexandroupolis, Alexandroupolis, Evros, Greece
  • Dimitriadis, Chrysostomos, Ippokrateio Hospital of Thessaloniki, Thessaloniki, Greece
  • Dounousi, Evangelia, University of Ioannina, Ioannina, Greece
  • Apostolou, Theofanis, "Ant. Mpilis" Nephrology Department Evaggelismos Hospital, Athens, Greece
  • Passadakis, Ploumis Stavros, Democritus University of Thrace, Alexandroupolis, Greece
  • Tsirpanlis, George I., G. Genimatas General Hospital , Athens, Greece
Background

Peritoneal membrane transport characteristics vary in peritoneal dialysis (PD) patients and have been related to patient and technique survival.

Methods

Data from PD patients from 10 PD units in Greece were retrospectively analyzed. Patients with a history of early catheter dysfunction or leakage were excluded. 163 patiens (100 male and 63 female) were finally included, whose first PET test was performed within 2 months after PD catheter insertion. Patients were divided into 4 sub-groups according to 4 hr D/P creatinine ratio; fast as 1SD above mean, average fast as between mean and mean+1SD, average slow as mean-1SD and slow as below 1SD from the mean. Ordinal regression analysis was performed to identify risk factors for faster membrane permeability.

Results

The median age of the study group was 58.2 (range 21-88) years. The etiology of ESRD was unknown in 26.5%, diabetes mellitus in 19.5%, hypertension/nephrosclerosis in 18%, glumerolonephritis in 17.2%, polycystic kidney disease in 10.5%.
Gender and BMI did not differ significantly between sub-groups of patients (p>0.05). In univariate analysis age (p=0.02), the history of diabetes mellitus (p=0.03) and lipidemia (p=0.03), as well as hemoglobin (p=0.03) and albumin concentrations (p=0.01) were significantly different among the four sub-groups. In multivariate analysis only the presence of diabetes mellitus (OR=1.98, p= 0.045) and hemoglobin levels (OR: 0.76, p=0.01) were independently associated with higher membrane permeability.

Conclusion

Diabetes mellitus and anemia are independent predictors of membrane transport characteristics in patients starting PD.