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Kidney Week

Abstract: FR-PO1151

Risk Factors for Progression of CKD in Children: Results from the Korean Cohort Study for Outcome in Patients with Pediatric CKD (KNOW-Ped CKD)

Session Information

  • Pediatric Nephrology - I
    October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

  • 1600 Pediatric Nephrology

Authors

  • Ahn, Yo Han, Seoul National University Bundang Hospital, Seongnam, Korea (the Republic of)
  • Choi, Hyun Jin, Seoul National University Children's Hospital, Seoul, Korea (the Republic of)
  • Han, Kyoung Hee, Jeju National University School of Medicine, Jeju, Korea (the Republic of)
  • Kim, Seong heon, Pusan National University Children's Hospital, Yangsan, Korea (the Republic of)
  • Cho, Heeyeon, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
  • Cho, Min Hyun, Kyungpook National University, School of Medicine, Daegu, Korea (the Republic of)
  • Shin, Jae Il, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea (the Republic of)
  • Lee, Joo Hoon, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea (the Republic of)
  • Kang, Hee Gyung, Seoul National University Children's Hospital, Seoul, Korea (the Republic of)
  • Park, Young seo, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea (the Republic of)
  • Cheong, Hae Il, Seoul National University Children's Hospital, Seoul, Korea (the Republic of)
  • Ha, IL-Soo, Seoul National University Children's Hospital, Seoul, Korea (the Republic of)
Background

The prevalence of chronic kidney disease (CKD) has increased over the last decades. Several large studies of Western countries have reported risk factors of CKD progression in pediatric patients, while comprehensive studies on pediatric CKD are rare in Asian countries. We aimed to evaluate risk factors for the progression of CKD of Korea using KNOW-Ped CKD data.

Methods

In KNOW-PedCKD, 437 children with stage 1 to 5 of CKD were enrolled and 432 patients were followed more than 6 months between July 2011 and May 2017. The progression of CKD was defined as a composite renal event of renal replacement therapy or a ≥50% decline in estimated glomerular filtration rate. The baseline clinical and laboratory variables were analyzed.

Results

The progression of CKD occurred in 136 (31.4%) patients after median follow ups of 1.9 (IQR 0.7-3.2) years. In Kaplan-Meier analysis, the median renal survival of all analyzed CKD patients was estimated as 5.2 years. In multivariate analysis, after adjustment with Cox regression model, 6 variables remained as independent risk factors of CKD progression: male sex, CKD stage 4 and 5, hypertension, urine protein/creatinine ratio ≥0.5 mg/mg, serum albumin <3.8 mg/dL, and anemia. Among them, proteinuria, hypoalbuminemia, hypertension and anemia could be modifiable and treatable, in accordance to previous findings in the Western studies.

Conclusion

In KNOW-pedCKD cohort, risk factors for CKD progression in Korean pediatric patients were found, including modifiable factors. Applying these findings to the clinic might improve the outcome of pediatric CKD.

Funding

  • Government Support - Non-U.S.