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Abstract: SA-PO528

The Risk Factors Analysis of Idiopathic Membranous Nephropathy Complicated with AKI

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical, Outcomes, and Trials

Authors

  • Xie, Yi-yi, The second people''s hospital of nanning, Nanning, China
  • Xie, Li-jun, First Affiliated Hospital of Guangxi Medical University, Nanning, GuangXi, China
  • Liao, Yunhua, First Affiliated Hospital of Guangxi Medical University, Nanning, GuangXi, China
Background

Idiopathic membranous nephropathy (IMN) is the most conmon pathological types for nephrotic syndrome. In Chinese population, the proportion of IMN in primary glomerular disease increased obviously in recent years. Acute kidney injury(AKI) is a common complication of IMN. The risk factors of IMN complicate with AKI were unknown.

Methods

We collected the clinical data of 129 IMN patients diagnosed by renal biopsy from March 2011 to October 2015 in the First Affiliated Hospital of Guangxi Medical University , including 35 IMN patients complicated with AKI (AKI group) and 94 IMN patients without AKI (Non-AKI group). The age, blood pressure, BMI, blood homocysteine, blood 25(OH) vit-D3, 24h urinary protein, many other laboratory parameters and pathological parameters were compared between these two group. Single factor analysis and multivariate analysis were conducted to explore the independent risk factors of AKI.

Results

The age, systolic blood pressure(SBP), blood homocysteine, blood 25(OH) vit-D3, 24h urinary protein, blood IgG and blood IgG/C3 showed significant statistically differences between these two group (P <0.05). In AKI group, age, SBP, 24h urinary protein, blood homocysteine was higher than those in non-AKI group, but blood 25(OH) vit-D3, blood IgG, blood IgG/C3 was lower than those in non-AKI group. The SBP, level of blood homocyhsteine, level of low-density lipoprotein cholesterol, and level of 24 urinary protein was positively correlated with the occurrence of AKI (P<0.05). However, the level of 25(OH) vit-D3, blood IgG and blood IgG/C3 was negatively correlated with the occurrence of AKI (P <0.05). In multivariate analysis, high blood homocysteine, high 24h urinary protein, hypertension, high pathological stage was the risk factors of AKI.

Conclusion

The IMN patients, with advancing age, higher SBP, higher serum homocysteine, lower serum 25(OH) vit-D3, lower IgG/C3 and higher pathological stage were more prone to complicate with AKI.

Funding

  • Government Support - Non-U.S.