Kidney Week

Abstract: FR-PO172

The Plasma Growth Differentiation Factor-15 Levels as Useful Biomarker for Renal Impairment in the Elderly: Korean Frailty and Aging Cohort Study

Session Information

• CKD: Epidemiology, Risk Factors, Prevention - II
  October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 1901 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Ihm, Hyung-seok, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)

Hyung-seok Ihm,

• Kim, Jin sug, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)

Jin sug Kim,

• Jung, Su Woong, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)

Su Woong Jung,

• Ihm, Chun-Gyoo, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)

Chun-Gyoo Ihm,

• Jeong, Kyung-hwan, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)

Kyung-hwan Jeong,

• Lee, Tae won, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)

Tae won Lee,

• Lee, Ji yung, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)

Ji yung Lee,

• Hwang, Hyeon Seok, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)

Hyeon Seok Hwang,

Background

Growth differentiation factor-15 (GDF-15) expression has been reported to increase in response to tissue damage, and has recently emerged as a useful biomarker for various diseases. Although accumulating evidence supports the prognostic value of GDF-15 in renal impairment, few studies have analyzed it in the elderly. Thus, we conducted a cross-sectional study to investigate the association between plasma GDF-15 level and renal function in the elderly.

Methods

The present study was based on the baseline data of the Korean Frailty and Aging Cohort Study (KFACS), a nationwide cohort study that began in 2016. Of the 1,559 participants assessed in the first year, 443 with available plasma GDF-15 data were enrolled in this study. We investigated the association of plasma GDF-15 level with clinical and biochemical parameters. The study population was divided into two groups according to renal function (chronic kidney disease [CKD] and non-CKD groups) to analyze diagnostic predictive value for CKD.

Results

In a simple regression analysis, the level of plasma GDF-15 was negatively correlated with the estimated glomerular filtration rate (eGFR; r = -0.383, p < 0.001). In multiple linear regression analysis, GDF-15 level was still significantly correlated with eGFR, even after adjusting for other parameters (r = -0.259, p < 0.001). Plasma GDF-15 level was significantly higher in the elderly with CKD than in those with non-CKD (2364.025 ± 1052.23 ng/L and 1451.23 ± 835.79 ng/L, respectively, p < 0.001). The optimal cut-off value for CKD-predicting GDF-15 level was 1699.4 pg/mL (76.5% sensitivity and 76.0% specificity), as determined by receiver operating characteristic curve. The area under the curve was 0.793 ± 0.033 (95% CI 0.729-0.857, p < 0.001).

Conclusion

Our results suggest that plasma GDF-15 level can be a useful biomarker for renal impairment in the elderly. Further large and prospective studies of extended duration are needed.