ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: FR-PO172

The Plasma Growth Differentiation Factor-15 Levels as Useful Biomarker for Renal Impairment in the Elderly: Korean Frailty and Aging Cohort Study

Session Information

Category: CKD (Non-Dialysis)

  • 1901 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Ihm, Hyung-seok, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)
  • Kim, Jin sug, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)
  • Jung, Su Woong, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)
  • Ihm, Chun-Gyoo, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)
  • Jeong, Kyung-hwan, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)
  • Lee, Tae won, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)
  • Lee, Ji yung, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)
  • Hwang, Hyeon Seok, Kyung Hee University, School of Medicine, Seoul, Korea (the Republic of)
Background

Growth differentiation factor-15 (GDF-15) expression has been reported to increase in response to tissue damage, and has recently emerged as a useful biomarker for various diseases. Although accumulating evidence supports the prognostic value of GDF-15 in renal impairment, few studies have analyzed it in the elderly. Thus, we conducted a cross-sectional study to investigate the association between plasma GDF-15 level and renal function in the elderly.

Methods

The present study was based on the baseline data of the Korean Frailty and Aging Cohort Study (KFACS), a nationwide cohort study that began in 2016. Of the 1,559 participants assessed in the first year, 443 with available plasma GDF-15 data were enrolled in this study. We investigated the association of plasma GDF-15 level with clinical and biochemical parameters. The study population was divided into two groups according to renal function (chronic kidney disease [CKD] and non-CKD groups) to analyze diagnostic predictive value for CKD.

Results

In a simple regression analysis, the level of plasma GDF-15 was negatively correlated with the estimated glomerular filtration rate (eGFR; r = -0.383, p < 0.001). In multiple linear regression analysis, GDF-15 level was still significantly correlated with eGFR, even after adjusting for other parameters (r = -0.259, p < 0.001). Plasma GDF-15 level was significantly higher in the elderly with CKD than in those with non-CKD (2364.025 ± 1052.23 ng/L and 1451.23 ± 835.79 ng/L, respectively, p < 0.001). The optimal cut-off value for CKD-predicting GDF-15 level was 1699.4 pg/mL (76.5% sensitivity and 76.0% specificity), as determined by receiver operating characteristic curve. The area under the curve was 0.793 ± 0.033 (95% CI 0.729-0.857, p < 0.001).

Conclusion

Our results suggest that plasma GDF-15 level can be a useful biomarker for renal impairment in the elderly. Further large and prospective studies of extended duration are needed.