Kidney Week

Abstract: TH-PO148

The Incidence and Related Factors of Post-Transplantation Diabetes Mellitus within 1-Year After Kidney Transplantation: Korean Cohort Study for Outcome in Patients with Kidney Transplantation (KNOW-KT)

Session Information

• Transplantation: Cardiovascular and Metabolic Diseases
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 1802 Transplantation: Clinical

Authors

• Han, Seungyeup, Keimyung University School of Medicine, Daegu, Korea (the Republic of)

Seungyeup Han,

• Kang, Seong Sik, Keimyung University School of Medicine, Daegu, Korea (the Republic of)

Seong Sik Kang,

• Park, Hayeon, Keimyung University School of Medicine, Daegu, Korea (the Republic of)

Hayeon Park,

• Paek, Jin hyuk, Keimyung University School of Medicine, Daegu, Korea (the Republic of)

Jin hyuk Paek,

• Yeo, Sang Mok, Keimyung University School of Medicine, Daegu, Korea (the Republic of)

Sang Mok Yeo,

• Park, Woo Yeong, Keimyung University School of Medicine, Daegu, Korea (the Republic of)

Woo Yeong Park,

• Jin, Kyubok, Keimyung University School of Medicine, Daegu, Korea (the Republic of)

Kyubok Jin,

• Park, Sung Bae, Keimyung University School of Medicine, Daegu, Korea (the Republic of)

Sung Bae Park,

Group or Team Name

• KNOW-KT Study Group

Background

Posttransplantation diabetes mellitus (PTDM) is associated with poor graft survival and greater mortality. The incidence of PTDM after kidney transplantation (KT) reported to date is varied from 10-74% and varies by country and race. There are few nationwide cohort study reports on the incidence of PTDM and associated risk factors in Korea. The purpose of this study was to evaluate incidence and related factors of PTDM early after KT in Korea.

Methods

A total of 1,080 recipients were enrolled in KoreaN cohort study for Outcome in patients With Kidney Transplantation (KNOW-KT) between July 2012 and August 2016. This study included 723 recipients, excluding 273 patients with pretransplant DM and 84 patients lost of follow-up within 1-year after KT. We evaluated associated factors of PTDM within 1-year after KT.

Results

Among the 723 recipients, 85 (11.8%) was diagnosed and treated with PTDM. In the univariate logistic regression analysis, pretransplantation variables that showed significant associations with PTDM were older recipient age, end-stage renal disease due to polycystic kidney disease, smoking history, high body mass index, waist–hip ratio (WHR), HbA1C levels, numbers of HLA total and HLA-DR mismatches and lower transferrin saturation. Posttransplant variables that were significantly associated with PTDM were high WHR, triglyceride/high density lipoprotein ratio, and serum triglyceride levels, low serum albumin levels, acute rejection, statin use, and vitamin D replacement. In the multivariate logistic regression analysis, predictors of PTDM were older recipient age, high WHR and HbA1C before KT, and statin use after KT.

Conclusion

In Korean cohort study, the incidence of PTDM was 11.8%. Risk factors for PTDM within 1-year after KT were older recipient age, higher WHR and HbA1C before KT. To prevent PTDM, it is important to control the overweight and abdominal obesity through life style modification prior to KT.