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Abstract: TH-PO219

Factors Affecting Progressive Vascular Calcification in Hemodialysis Patients

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical

Authors

  • Lee, Dong-Young, Veterans Health Service medical center, Seoul, Korea (the Republic of)
  • Kim, Beom, Veterans Health Service Medical Center, Seoul, Korea (the Republic of)
  • Moon, Kyoung hyoub, Vetrans Health Service Medical Center, Seoul, Korea (the Republic of)
  • Kim, Hye won, Korea university Anam Hospital, Seoul, Korea (the Republic of)
Background

It is known that patients who have done dialysis due to end stage renal disease have progressive vascular calcification, and that the more severe it is, the more frequent the occurrence and resulting death of cardiovascular disease. But so far very little is known about the causes of progressive vascular calcification. We aimed to investigate the risk factors for progressive abdominal aortic calcification in patients doing hemodialysis.

Methods

We conducted cross-sectional study of 281 subjects at six centers who agreed to this study and underwent lateral lumbar radiography. Kauppila score was used to measure abdominal aortic calcification, and progressive vascular calcification was defined as a median vascular calcification score of 7 or more. Radiographs of the lateral lumbar spine were analyzed by two staff members and the identities of the Kauppila scores between the two were 91%.

Results

The mean age of the 281 hemodialysis patients was 62.7 years, and 250 patients (89%) had calcification. The distribution of the abdominal aortic calcification score was 49.5% in 0-6, 28.5% in 7-12, 17.1% in 13-18, and 5% in 19-24. The risk factors for progressive vascular calcification were Kt / V (OR 8.2, 95% CI 2.39-28.1), cardiovascular disease (OR 2.54, 95% CI 1.27-5.06), DM (OR 2.38, 95% CI 1.21-4.68), age (OR 1.05, 95% CI 1.03-1.08), serum Ca (OR 1.63 1.13-2.34), total CO2 (OR 1.15, 95% CI 1.04-1.27), serum Na (OR 0.86 95% CI 0.79-0.93) and serum chloride (OR 0.88, 95% CI 0.82-0.94).

Conclusion

Several factors were associated with progressive vascular calcification. Further longitudinal studies are needed to determine the association of these factors with progressive vascular calcification.