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Abstract: TH-PO1028

Association of the CMIP Gene Single Nucleotide Polymorphism with Serum Lipids Parameter of IgA Nephropathy

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Pan, Ling, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
  • Liao, Yunhua, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
  • Li, Xiaohua, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
  • Mo, Manqiu, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Background

The effect of dyslipidemia on cardiovascular complications and renal progression in IgAN has been confirmed. The CMIP gene was recently found to be closely related to TC, LDL-C and HDL-C levels. The relationship between dyslipidemia of IgAN and CMIP gene polymorphism has not been reported so far.

Methods

Study subjects were selected in the First Affiliated Hospital of Guangxi Medical University from August 2010 to December 2017. TC, TG, HDL-C, LDL-C, ApoA1 and ApoB levels were tested. Blood samples were extracted for DNA, PCR amplification, electrophoresis imaging. PCR products were sent to measure genotypes. The genotypic and allelic frequencies were measured. We explored the relationship between CMIP gene SNPs and serum lipid levels, and analyzed the risk factors of dyslipidemia.

Results

The study included 543 patients, 51.7%were dyslipidemia. The genotype and allele frequency of CMIP rs16955379 were statistically different between the two groups ((P < 0.05). TG, HDL, BP, tubular atrophy and interstitial fibrosis(TA/IF) were significantly different between CMIP rs16955379 C allele carriers and non-carriers. TC, BP, Scr, UA, urine protein, renal dysfunction, and TA/IF were significantly different between CMIP rs2925979 A allele carriers and non-carriers.TC level was associated with rs16955379 C allele carrier, hypertension, alcohol and UA. TG level was associated with renal dysfunction, rs16955379 C alleles carrier, alcohol, smoking, BMI, UA, and TA/IF. HDL was associated with rs16955379 C allele carrier, UA, renal dysfunction, and mesangial cell proliferation. LDL was associated with rs16955379 C allele carrier, hypertension, and UA(P < 0.05, respectively). There was a linkage disequilibra(LD) between rs16955379 and rs2925979, and rs2925979G-rs16955379T was the most common haplotype. The haplotype frequencies of CMIP SNPs were significantly different between dyslipidemia and normal group (P < 0.05).

Conclusion

About half of IgAN patients had dyslipidemia. The genotypic and allelic frequencies of rs16955379 were significant different between dyslipidemia group and normal group. There were significant differences in several lipid levels between CMIP SNPs different allele carriers. There was a LD between rs292597 and rs16955379. The most common haplotype was rs2925979G-rs16955379T. The related haplotypes increased the risk of dyslipidemia in IgAN.

Funding

  • Government Support - Non-U.S.