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Abstract: TH-PO619

Preliminary Analyses on Dietary Inflammatory Index Among Participants in the Palm Tocotrienols in Chronic Hemodialysis (PATCH, USA) Study

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1301 Health Maintenance, Nutrition, and Metabolism: Basic

Authors

  • Tallman, Dina A., Wayne State University , Detroit, Michigan, United States
  • Latifi, Eno, Wayne State University , Detroit, Michigan, United States
  • Kaur, Deepinder, Wayne State University , Detroit, Michigan, United States
  • Khosla, Pramod, Wayne State University , Detroit, Michigan, United States
Background

Inflammation is a predictor of mortality in hemodialysis (HD) patients. The dietary inflammatory index (DII) assesses the potential effect of diet on systemic inflammation. The aim of this preliminary analysis was to evaluate the use of DII and examine the associations between DII, diet composition and key anthropometry.

Methods

Dietary 24 hr recalls were collected at baseline from HD patients participating in the PATCH clinical trial (NCT02358967), an ongoing one year double-blind intervention (300 mg tocotrienols or placebo, daily) which includes quarterly anthropometric measures. Data was analyzed using Food Processor ESHA Research. After accounting for under reporters, the DII score was calculated from 85 patients (Age 62 ± 12 yrs., 67% men, 95% African American). Handgrip strength (HGS) was measured using a Jamar dynamometer for 48 of the subjects. A z-score transformation was applied to mean baseline HGS scores using normative grip strength data and these standard scores were compared with clinical and demographic characteristics collected from medical records.

Results

DII showed a significant positive correlation with percent calories from saturated fatty acids (r = 0.38) and significant negative correlations with dietary monounsaturated (r = -0.38) and polyunsaturated fatty acids (r = -0.37), vitamin E tocopherol (r = -0.69), the vitamin E to linoleic acid ratio (r = -0.23), and the phosphorus to protein ratio (r=-0.43). When subjects were divided into tertiles based on DII score, significant decreasing trends were observed for HGS and significant increasing trends for serum phosphorus. Weaker grip strengths were significantly and positively correlated with serum ferritin levels between 800 and 1200 ng/ml for a sub-set of the population (n = 18; r = -0.54).

Conclusion

Inflammation may be implicated in CKD induced muscle loss. The restrictive nature of the renal diet, though controlling serum phosphorus, was proinflammatory for this study group. Thus, DII may be a useful tool for exploring the role of specific dietary fatty acids and antioxidants to the contribution of inflammation in the African American HD population.
(Supported by the Malaysian Palm Oil Board, Government of Malaysia)

Funding

  • Government Support - Non-U.S.