ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: TH-PO316

Deep Cerebral Microbleeds Associate with Cognitive Impairment in Dialysis Patients: A Cross-sectional Observational Study

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Yujun, Qian, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China, Beijing, China
  • Zheng, Ke, Peking Union Medical College Hospital, Beijing, China
  • Li, Xuemei, Peking Union Medical College Hospital, Beijing, China
Background

Cerebral microbleeds (CMBs) are common in dialysis patients, and different location of CMBs resulted from different pathologies. The relationship between CMBs and cognitive impairment (CI) in dialysis patients was controversial. This study aimed to explore whether the distribution of CMBs affects cognitive function in dialysis patients.

Methods

In this cross-sectional study, we enrolled a total of 189 dialysis patients. Patients were divided into 4 groups: without-MBs group, strictly lobar group, strictly deep group, and mixed group. A wide range of cognitive tests were administered to evaluate cognitive function.

Results

In our study, the prevalence of CMBs was 32.8%, 35.2% in HD patients and 29.7% in PD patients. 17 subjects (9.0%) classified as lobar group, 14 subjects (7.4%) as mixed group, and 31 subjects (16.4%) as deep group. Mean arterial pressure (MAP) was significantly associated with the lobar group and deep group. Dialysis vintage was associated with deep group only. Self-reported stroke history and current antiplatelet medication had relevance to the lobar group. There was a significant association between deep CMBs and impaired cognitive function, involving overall cognitive function, memory, language ability and executive function.

Conclusion

Deep CMBs are closely associated with global and specific cognitive impairment in dialysis patients.

Funding

  • Government Support - Non-U.S.