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Kidney Week

Abstract: TH-PO729

Congenital Renal Glycosuria Is Associated with Healthier Weight at Adolescence: Nationwide Cross Sectional Study of 2.38 Million Examinees

Session Information

Category: Genetic Diseases of the Kidney

  • 1002 Genetic Diseases of the Kidney: Non-Cystic

Author

  • Leiba, Adi, Assuta Ashdod Hospital, Ben Gurion University of the Negev, Ashdod, Israel
Background

Glucose filtered in the glomeruli is normally reabsorbed by the sodium coupled glucose transporters (SGLTs), mostly the SGLT2, located in the renal tubules. Mutations in the genes coding for these transporters were shown to cause renal glycosuria. It was shown recently in various studies that pharmacological inhibition of SGLT2 causing renal glycosuria is an effective treatment for diabetic patients. Among the desirable effects of these medications is weight lost and reduction of blood pressure. The aim of the current study is to investigate whether adolescents with renal glycosuria are less likely to be overweight or obese

Methods

Medical and socio-demographic data on 2,385,093 adolescents examined for medical fitness prior to military service from 1977 to 2016 were retrieved from the Israeli Defense Forces conscription center database. We conducted a cross sectional study to evaluate the association between renal glycosucria diagnosed in the conscription center and the overweight (85-95 BMI percentiles) and obesity (>95 bmi percentiles). Multinomial regression model were used.

Results

The final study cohort comprised of 2,388,163 conscripts of whom 1069 (0.045%) were assigned with numerical code meaning renal glycosuria not related to diabetes. The adjusted OR for overweight and obesity was 0.69 (95% CI, 0.54-0.89) and 0.60 (95% CI, 0.42-0.85), respectively.

Conclusion

Congenital Glycosuria may is associated with healthier metabolic profile, specifically less overweight and obesity, and this effect is already seen at adolescence