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Kidney Week

Abstract: TH-PO128

Application of New Hypertension Guidelines to Renal Transplant Recipients: Impact on Cardiovascular Outcome and Graft Survival

Session Information

Category: Transplantation

  • 1802 Transplantation: Clinical


  • Pagonas, Nikolaos, Ruhr-University Bochum, Germany, Herne, Germany
  • Seibert, Felix S., Ruhr-University Bochum, Germany, Herne, Germany
  • Bauer, Frederic, Ruhr-University Bochum, Germany, Herne, Germany
  • Rohn, Benjamin, Ruhr-University Bochum, Germany, Herne, Germany
  • Viebahn, Richard, Ruhr-University Bochum, Bochum, Germany
  • Babel, Nina, Ruhr-University Bochum, Germany, Herne, Germany
  • Westhoff, Timm H., Ruhr-University Bochum, Germany, Herne, Germany

Based on data of the SPRINT trial, American national guidelines recently reduced the blood pressure goal from 140/90 mm Hg to 130/80 mm Hg for subjects with increased cardiovascular risk, e. g. those with chronic kidney disease. To date it remains elusive whether renal transplant recipients benefit from these goals as well.


We performed a retrospective analysis of 877 patients who underwent kidney transplantation between 1997 and 2011 in three transplant centers in Germany (Berlin and Bochum) with a follow-up of 12 - 120 months. Blood pressure was obtained at regular follow-up examinations in the transplant outpatient clinic. Patient and graft survival was defined as composite endpoint. Subjects were stratified according to mean systolic blood pressure values < 130 mmHg, 130-139 mmHg, or ≥ 140 mmHg.


Mean SBP of the overall follow-up period was significantly associated with patient and graft survival. Cumulative survival was significantly higher for those patients with a systolic blood pressure (SBP) < 130 mmHg than those with 130-140 mmHg. Survival was lowest in renal transplant recipients with a mean SBP ≥ 140 mmHg. Analogously, mean SBP of the first 12 months posttransplant < 130 mmHg was associated with better cumulative patient and graft survival than higher blood pressure values in Kaplan Maier analyses.


Renal transplant recipients who achieve a mean systolic blood pressure < 130 mmHg have a significantly lower mortality and a better allograft outcome than with the conservative blood pressure goal < 140 mmHg. The new blood pressure targets should be considered suitable for renal transplant recipients as well.