Kidney Week

Abstract: FR-PO1128

Predictors of Remission in Collapsing Glomerulopathy

Session Information

• Glomerular Diseases: Clinical, Outcomes, Trials - II
  October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Glomerular Diseases

• 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

• Luvizotto, Mateus Justi, University of Sao Paulo, Brazil, São Paulo, Brazil

Mateus Justi Luvizotto,

• Sales, Gerard F., University of Sao Paulo, Brazil, São Paulo, Brazil

Gerard F. Sales,

• Neves, Precil D., University of Sao Paulo, Brazil, São Paulo, Brazil

Precil D. Neves,

• Yu, Luis, University of Sao Paulo, Brazil, São Paulo, Brazil

Luis Yu,

• Dias, Cristiane B., University of Sao Paulo, Brazil, São Paulo, Brazil

Cristiane B. Dias,

• Woronik, Viktoria, University of Sao Paulo, Brazil, São Paulo, Brazil

Viktoria Woronik,

• Jorge, Lectícia, University of Sao Paulo, Brazil, São Paulo, Brazil

Lectícia Jorge,

Background

Collapsing Glomerulopathy (CG) has usually been associated with poor renal outcomes. The goal of this study was to identify predictors of remission in the CG.

Methods

A retrospective analysis was performed on all CG diagnosed by kidney biopsy between 1996 and 2016. Clinical and laboratory data were collected at baseline and at the end of follow up. Remission has been defined as 50% reduction in baseline proteinuria and <3.5 g/day. Outcome was defined as ESRD or doubling of baseline creatinine.

Results

Logistic regression analysis showed that remission was significantly associated with a better renal outcome (OR 0.08, 95%CI 0.02-0.3, p<0.001), even after adjustments for baseline CKD-EPI and proteinuria. Clinical features of the groups with and without remission are summarized in Figure 1. A second logistic regression analysis showed that female and interstitial fibrosis are the only independent predictors associated with remission in CG (OR 0.28, 95%CI 0.09-0.84, p 0.02 and OR 10.9,95%CI 1.2-98 p 0.034)

Conclusion

Predicting remission with baseline features is difficult, but female and patients without interstitial fibrosis are more likely to achieve remission.
Moreover, patients with CG who showed remission had a better outcome and this should be (a goal of therapy)attempted.