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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Abstract: INFO09

The George M. O'Brien Kidney Translational Core Center at the University of Michigan

Session Information

  • Informational Posters
    October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category:

  • No subcategory defined

Authors

  • Pennathur, Subramaniam, University of Michigan, Ann Arbor, Michigan, United States
  • Brosius, Frank C., University of Arizona, Tucson, Arizona, United States
  • Bellovich, Keith A., St. John Hospital Medical Center, Detroit, Michigan, United States
  • Bhat, Zeenat Yousuf, Wayne State University , Detroit, Michigan, United States
  • Gadegbeku, Crystal A., Temple University, Philadelphia, Pennsylvania, United States
  • Gipson, Debbie S., University of Michigan Mott Children's Hospital, Ann Arbor, Michigan, United States
  • Lienczewski, Chrysta C., University of Michigan Medical Center, Ann Arbor, Michigan, United States
  • Ju, Wenjun, University of Michigan, Ann Arbor, Michigan, United States
  • Sas, Kelli M., University of Michigan Health System, Ann Arbor, Michigan, United States
  • Massengill, Susan F., Levine Children's Hospital, Charlotte, North Carolina, United States
  • Mceachin, Richard C., Univ Michigan, Ann Arbor, Michigan, United States
  • Wiggins, Roger C., University of Michigan Health System, Ann Arbor, Michigan, United States
  • Kretzler, Matthias, U.Michigan, Ann Arbor, Michigan, United States
Description

Recent advances have allowed the development of molecular maps to define chronic kidney disease (CKD) in new, accurate and personalized ways. These developments make possible the prediction of outcomes and response to therapy and the identification of key molecular targets for treatment of CKD in individual patients. Identification of such targets entails close collaboration between teams of investigators to collect and annotate samples from well characterized CKD subjects. In addition, technologies are needed that support information exchange, robust databanks, and data integration to define key pathways driving CKD pathogenesis.
The O'Brien Kidney Translational Core Center at the University of Michigan provides such biobanking, databank structure and bioinformatic support to basic and clinical investigators to allow them to pursue critical precision medicine investigations of humans with CKD.
The Clinical Phenotyping and Biobank Core has enrolled over 1675 patients with CKD from 5 sites and banked their samples and clinical information providing a valuable resource for efficient discovery. Multiple specific research studies have now successfully utilized these resources.
The Applied Systems Biology Core and its online analytical tool, Nephroseq, have assisted hundreds of investigators around the world in approaches to the analysis of large transcriptomic datasets and other systems-level, biological studies of patients with CKD.
The Center’s Bioinformatics Core provides access to computational applications and skilled professional support in bioinformatics and biostatistics and will now be providing back-end maintenance of Nephroseq.
The Administrative Core directs pilot and small grants, student training and discount programs with the goal of helping new and established researchers utilize systems biological and translational research tools. Together these cores provide a comprehensive translational research support for novel research into classification and treatment of chronic kidney diseases.
All interested academic investigators around the world are invited to make use of these services and to contact us for information and consultation.

Funding

  • National Institutes of Health