Abstract: FR-PO1164
Evaluating Renal Outcomes in Adolescents Born Extremely Premature of the ELGAN (Extremely Low Gestational Age Newborn) Cohort
Session Information
- Pediatric Nephrology - I
October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1600 Pediatric Nephrology
Authors
- Sanderson, Keia, University of North Carolina Kidney Center, Chapel Hill, North Carolina, United States
- Chang, Emily H., UNC Kidney Center, Chapel Hill, North Carolina, United States
- Primack, William A., University of North Carolina, Chapel Hill, North Carolina, United States
- O'Shea, Michael, University of North Carolina, Chapel Hill, North Carolina, United States
Background
Premature birth is associated with decreased nephron number and an increased lifetime risk for chronic kidney disease (CKD). Yet there is lack of recommendation for renal follow up of children born prematurely.
The aim of the study is to characterize the prevalence of macroalbuminuria, elevated blood pressure, and/or abnormal renal mass (predictors of CKD) in adolescents with a history of extremely premature birth.
Methods
We obtained 2 manual blood pressures, a random urinalysis, and sonographic measurements of kidney length and volume on 17 consecutively enrolled 15-year old children born at <28 weeks gestation of the UNC Extremely Low Gestational Age Newborns (ELGAN) cohort.
Results
Of the 17 currently enrolled participants, 65% were male, 53% were Caucasian (33%identified as Hispanic) and 47% were African-American. Their mean age was 15 years. Median blood pressure was 115/69 mmHg with 35% of the cohort demonstrating elevated mean blood pressures. Median urine albumin/creatinine ratio was 7.75µg/mg with 24% of the cohort demonstrating significant random macroalbuminuria (>30µg/mg). Sonographic measurements are listed in Table 1. Twenty-nine percent of participants demonstrated abnormal renal mass (18% right renal hypoplasia, 6% right renal hypertrophy, 6% left renal hypoplasia, 6% left renal hypertrophy). No gross renal anatomical abnormalities were seen via ultrasound.
Conclusion
Nearly half (47%) of adolescents in this extremely low gestational age cohort were found to have abnormal renal mass, macroalbuminuria, or elevated blood pressures. Enrollment is ongoing. This data suggests that renal follow up of children with a history of extremely premature birth should be considered.
Table 1: Sonographic Renal Measurements of Adolescents of the ELGAN cohort
| ELGAN Cohort | Normative Data | |
| Mean Right Kidney Length(cm) | 9.09 (+/-0.85) | 9.2(+/-0.7) |
| Mean Right Body Surface Area related Kidney Volume (ml/m2) | 61.82(+/-17.3) | 45-85 |
| Mean Left Kidney Length(cm) | 9.47(+/-1.1) | 9.9(+/-0.6) |
| Mean Left Body Surface Area related Kidney Volume (ml/m2) | 67.77(+/-17.6) | 45-85 |
| Mean Total Kidney Volume (cm3) | 219 (+/- 78.5) | 236.43(+/-14.58) |
Funding
- Other NIH Support