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Abstract: SA-PO450

Vitamin D Receptor Gene Polymorphisms in Childhood Idiopathic Nephrotic Syndrome

Session Information

  • Pediatric Nephrology - II
    October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

  • 1600 Pediatric Nephrology

Authors

  • Chiou, Yee-Hsuan, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
  • Huang, Shiao-Ping, Fooyin University, Kaohsiung, Taiwan
  • Fang, Nai-Wen, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Background

Idiopathic nephrotic syndrome (INS) is the most frequent type of nephrotic syndrome in children. The pathogenesis of remains controversial and may be mediated by the immune system and the imbalance between T-helper cell subtype 1 (Th1) and subtype 2 (Th2) cytokines, which are regulated by the vitamin D. Vitamin D exerts its effects through its receptor (VDR). Its response to steroids treatment are also varied. The aim of this study was to analyze the correlation between the VDR gene polymorphisms and the response to steroids treatment in INS children.

Methods

Thirty four patients with INS were enrolled and divided into 2 groups: 18 steroid-sensitive (SS) and 16 steroid-resistance (SR). To analyze the VDR gene polymorphisms, the SNP genotyping for Fok1, Apa1, Cdx2, Taq1, Bsm1 were performed using TaqMan Genotyping Assays. The genotypic and allele frequency were analyzed.

Results

The Apa1 C allele was associated with steroid resistance then A allele [OR 8.75, p=0.009]. The frequency of the C allele was significantly higher in SR than in SS subjects (0.84 vs. 0.47, respectively). The Bsm1 G allele was associated with steroid resistance then A allele [OR 7.00, p=0.017]. The frequency of the G allele was significantly higher in SR than in SS subjects (0.88 vs. 0.50, respectively). The Fok1 C allele was associated with steroid resistance then T allele [odds ratio (OR) 6.00, p=0.015]. The frequency of the C allele was significantly higher in SR than in SS subjects (0.66 vs. 0.33, respectively). There was no significant correlation in Cdx2 and Taq1 polymorphisms in VDR gene between treatment response.

Conclusion

Our results indicate that among our pediatric patients with INS, the VDR gene polymorphism: Fok1, Apa1, and Bsm1 were associated with steroid resistance; while the Cdx2 and Taq1 gene polymorphisms showed no statistical significance between these 2 groups.

Funding

  • Government Support - Non-U.S.