Kidney Week

Abstract: SA-PO398

Factors Associated with Incident Diabetes in Patients with Glomerular Disease: The CureGN Study

Session Information

• Glomerular Diseases: Clinical, Outcomes, Trials - III
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Glomerular Diseases

• 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

• Mottl, Amy K., University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Amy K. Mottl,

• Mansfield, Sarah, Arbor Research, Ann Arbor, Michigan, United States

Sarah Mansfield,

• Palmer, Matthew, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Matthew Palmer,

• Bomback, Andrew S., Columbia University, New York, New York, United States

Andrew S. Bomback,

• Nester, Carla M., University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

Carla M. Nester,

• Royal, Virginie, Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada

Virginie Royal,

• Barisoni, L., U. Miami, Miller School of Medicine, Miami Beach, Florida, United States

L. Barisoni,

• Stokes, Michael Barry, Columbia University Medical Center, New York, New York, United States

Michael Barry Stokes,

• Jennette, J. Charles, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

J. Charles Jennette,

• Kretzler, Matthias, U.Michigan, Ann Arbor, Michigan, United States

Matthias Kretzler,

• Tuttle, Katherine R., University of Washington School of Medicine, Spokane, Washington, United States

Katherine R. Tuttle,

• Nast, Cynthia C., Cedars-Sinai Medical Center, Los Angeles, California, United States

Cynthia C. Nast,

Background

Glomerular disease is often complicated by incident diabetes which may raise the long-term risk:benefit ratio of immunosuppressive treatment. There is a paucity of information regarding descriptive characteristics of individuals with glomerular disease and incident diabetes.

Methods

We studied 2009 individuals from the CureGN Cohort Study, an observational cohort study of people with IgA Nephropathy/Vasculitis (IgAN/IgAV), Membranous Nephropathy (MN), Focal Segmental Glomerulosclerosis (FSGS) and Minimal Change Disease (MCD), followed prospectively starting less than 5 years after kidney biopsy. We compared sociodemographic and clinical characteristics of individuals with versus without incident diabetes diagnosed after kidney biopsy. Statistical significance was calculated using Chi-square or Fisher’s exact test for categorical or Kruskal-Wallis test for continuous variables.

Results

There were 71 individuals with incident diabetes diagnosed a median of 4 (IQR 0-22) months after kidney biopsy. Diabetes was considered medication induced in 44 (62%) and 75% were treated with insulin. Characteristics of individuals with and without incident diabetes are shown in the table. Incident diabetes was more frequent in MN than in other glomerular diseases. Patients with versus without incident diabetes were older, more likely to have a family history of diabetes, and had a greater prevalence of obesity, smoking, hypertension and cardiovascular disease at enrollment. There was no difference in cumulative exposure to steroids between those with versus without incident diabetes.

Conclusion

Incident diabetes was more common in MN than other glomerular diseases, possibly due to older age at presentation of this disease. The absence of a difference in steroid exposure between those with versus without incident diabetes was unexpected and will be the focus of future analyses.

Funding

• NIDDK Support