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Kidney Week

Abstract: SA-PO488

Epidemiology of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Olmsted County

Session Information

  • ADPKD: Clinical Studies
    October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidney

  • 1001 Genetic Diseases of the Kidney: Cystic

Authors

  • Suwabe, Tatsuya, Mayo Clinic, Rochester, Minnesota, United States
  • Chamberlain, Alanna, Mayo Clinic, Rochester, Minnesota, United States
  • Cornec-Le Gall, Emilie, Centre Hospitalier Universitaire de Brest, BREST, France
  • Killian, Jill M., Mayo Clinic, Rochester, Minnesota, United States
  • Harris, Peter C., Mayo Clinic, Rochester, Minnesota, United States
  • Torres, Vicente E., Mayo Clinic, Rochester, Minnesota, United States
Background

ADPKD is the most common inherited kidney disease. A prior study in Olmsted County estimated an incidence of ADPKD of 1.38 per 100,000 during 1935–1980; however, contemporary data on the incidence of ADPKD are scarce. We aimed to determine the incidence of ADPKD in Olmsted County, MN during 1980-2016.

Methods

Mayo Clinic and Olmsted Medical Center (OMC) deliver most health care to Olmsted County residents. We searched diagnostic codes and the Mayo Clinic and OMC radiology databases to identify subjects and all medical records were reviewed to validate ADPKD diagnoses using the following criteria. Diagnosis of definite ADPKD was based on radiographic findings plus family history of ADPKD or genetic testing; likely ADPKD, on >10 cysts in each kidney without advanced CKD or different renal cystic diseases; possible ADPKD, on cyst number exceeding the 97.5 percentile in kidney donors of the same sex and age. Incidence of ADPKD during 1980-2016 and point prevalences for the year 2010 were calculated.

Results

We reviewed medical charts and abdominal images and/or radiology reports of 1,231 subjects with diagnostic codes of cystic disease during 1980-2016, and the medical charts and abdominal CT or MR scans of 2,765 subjects with multiple cysts from radiology databases during 1997-2016. 364 patients with incident ADPKD (85 definite, 45 likely, 234 possible) were identified. Overall age and sex adjusted annual incidence rates of definite ADPKD were 1.79 (95% CI: 1.40, 2.17) and those of definite or likely ADPKD 3.06 (2.52, 3.60) per 100,000 person-years. The peak incidence rate of definite and likely cases was 5.27 (3.07, 8.44) in the 60-69 year age group. Incidence rates of possible ADPKD increased markedly after 1997 when CT and MRI became available electronically. On January 1, 2010, the overall age and sex adjusted prevalence of definite ADPKD was 47.0 (35.4, 58.5), definite or likely ADPKD was 68.0 (53.9, 82.1) and definite, likely or possible ADPKD was 123.9 (104.6, 143.2) per 100,000 population.

Conclusion

The incidence of definite or likely ADPKD was 2.22 times higher than in the 1935-1980 study likely due to more comprehensive ascertainment of the population. Genetic testing will be necessary to determine how many of the patients classified as possible cases have ADPKD or another genetic renal cystic disease.