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Abstract: TH-PO471

Clinical Characteristics Enhancing the Predictive Ability of C-Reactive Protein on Incident Hypertension

Session Information

Category: Hypertension and CVD

  • 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

  • Lee, Dong-Young, Veterans Health Service medical center, Seoul, Korea (the Republic of)
  • Moon, Kyoung hyoub, Vetrans Health Service Medical Center, Seoul, Korea (the Republic of)
Background

Previous studies have demonstrated that the elevated CRP predicts the development of cardiovascular disease. However, it is still argued whether elevated CRP was independently associated with the elevation of blood pressure. This study was to investigate the predictability of CRP level on incident hypertension according to the clinical characteristics in normotensive general Korean population.

Methods

We examined 7,481 normotensive subjects from Korean Genome and Epidemiology Study (KoGES). They were stratified into 4 groups by quintiles of their baseline CRP levels, and followed-up for 10 years to monitor the incident hypertension. Cox proportional hazards model was used to calculate the hazard ratios (HRs) and 95% confidential interval (CI) for hypertension according to quintiles of CRP level. Additionally, subgroup analysis was performed by gender, obesity/non-obesity, dysglycemia/normal glycemia and middle (40-54 years) /old age (55-69 years).

Results

In all participants, compared to group of quintile 1, adjusted HRs for hypertension significantly increased in group of quintile 4 (1.22 [95% CI 1.04-1.43]). In subgroup analyses, women, obese and middle-aged subgroup showed the statistically significant HRs for hypertension at quintile 4 (women subgroup: 1.37 [95% CI 1.09-1.72]; obese subgroup: 1.33 [95% CI 1.07-1.66]; middle-aged subgroup: 1.31 [95% CI 1.07-1.59]), and dysglycemic subgroup had the statistically significant HRs for T2DM at both quintile 3 (1.33 [95% CI 1.04-1.71]) and quintile 4 (1.34 [95% CI 1.04-1.73]).

Conclusion

Our results suggest that the predictability of CRP on hypertension is enhanced in clinical conditions including women, obesity, dysglycemia and middle age.