Kidney Week

Abstract: TH-PO1133

Association Between Serum Lipid Profiles and Cardiovascular Outcomes in CKD Patients: KNOW-CKD Study

Session Information

• CKD: Clinical, Outcomes, Trials - I
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 1902 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

• Choi, Arum, Yonsei University College of Medicine, Seodaemun-gu, SEOUL, Korea (the Republic of)

Arum Choi,

• Nam, Yooju, Yonsei University College of Medicine, Seodaemun-gu, SEOUL, Korea (the Republic of)

Yooju Nam,

• Lee, Seon yeong, Yonsei University College of Medicine, Seodaemun-gu, SEOUL, Korea (the Republic of)

Seon yeong Lee,

• Kim, Joohwan, Yonsei University College of Medicine, Seodaemun-gu, SEOUL, Korea (the Republic of)

Joohwan Kim,

• Nam, Ki Heon, Yonsei University College of Medicine, Seodaemun-gu, SEOUL, Korea (the Republic of)

Ki Heon Nam,

• Yoo, Tae-Hyun, Yonsei University College of Medicine, Seodaemun-gu, SEOUL, Korea (the Republic of)

Tae-Hyun Yoo,

• Han, Dae-Suk, Yonsei University College of Medicine, Seodaemun-gu, SEOUL, Korea (the Republic of)

Dae-Suk Han,

• Han, Seung Hyeok, Yonsei University College of Medicine, Seodaemun-gu, SEOUL, Korea (the Republic of)

Seung Hyeok Han,

Background

Dyslipidemia has been linked to an increased risk of cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). However, the role of individual lipid parameters in the development of cardiovascular events in the CKD population is not well established. Here, we analyzed the relative contribution of 4 lipid profiles such as total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides (TG) to the risk of cardiovascular morbidity and mortality in patients with non-dialysis CKD.

Methods

Among 2,238 patients with non-dialysis CKD enrolled in the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD), 1,728 patients who measured TC, LDL-C, HDL-C, and TG and were not previously diagnosed with cardiovascular disorders were included in the analysis. Study endpoint was a composite of major cardiovascular events or death.

Results

The mean age was 52.9 ± 12.1 years and 1,023 (59.2%) patients were males. The mean serum concentrations of TC, LDL-C, HDL-C, and TG were and 175.5 ± 38.5, 98.0 ± 31.2, 49.8 ± 15.6, and 156.9 ± 96.6 mg/dl, respectively. Among 1,728 patients, 860 (49.7%) patients were treated with lipid-lowering drugs. During the median follow-up duration of 3.0 years, 105 patients (6.1%) reached the composite end point. In the fully adjusted multivariable Cox models, HDL-C (HR, 1.05 per 10 mg/dl increase; 95% CI, 0.92-1.12; P = 0.50), TC (HR, 1.03 per 10 mg/dl increase; 95% CI, 0.98-1.09; P = 0.23), LDL-C (HR, 1.03 per 10 mg/dl increase; 95% CI, 0.97-1.10; P = 0.36), and TG (HR, 1.00 per 10 mg/dl increase; 95% CI, 0.98-1.02; P = 0.75) were not associated with increased risk of cardiovascular events or death. Furthermore, areas under the curve of these 4 lipids were similar and none of these parameters improved net reclassification improvement and integrated discrimination improvement for the prediction of cardiovascular morbidity and mortality.

Conclusion

This study showed that four lipid profile parameters did not predict the future adverse outcomes nor improved cardiovascular risk stratification in patients with CKD.