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Abstract: SA-PO1047

Diet and Renal Function in the ELSA-Brasil Cohort: A Mediation Analysis

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1302 Health Maintenance, Nutrition, and Metabolism: Clinical

Authors

  • Silva Junior, Geraldo B., University of Fortaleza, Fortaleza, Brazil
  • Fagundes xavier, Rosa malena, Federal University of Bahia, Salvador, Brazil
  • Aquino, Estela, Federal University of Bahia, Salvador, Brazil
  • Cardoso, Leticia, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
  • Salani mota, Rosa maria, Federal University of Ceara, Fortaleza, Brazil
  • Lopes, Antonio alberto, Federal University of Bahia, Salvador, Brazil
  • Mill, José geraldo, Federal University of Espirito Santo, Vitoria, Brazil
  • Bisi molina, Maria del carmen, Federal University of Espirito Santo, Vitoria, Brazil
  • Barreto, Sandhi, Federal University of Minas Gerais, Belo Horizonte, Brazil
  • Chor, Dora, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
  • Teles santos, Carlos, Federal University of Bahia, Salvador, Brazil
  • Lotufo, Paulo, University of Sao Paulo, Sao Paulo, Brazil
  • Alvim matos, Sheila, Federal University of Bahia, Salvador, Brazil
Background

Previous studies suggest the influence of diet on renal function. The aim of this study was to investigate the associations between diet and renal function among adults in Brazil.

Methods

The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is the largest cohort study in Latin America, with 15,105 participants from 6 cities in Brazil. We have identified 4 dietary patterns in this cohort: 1) Traditional Brazilian, 2) Low sugar/low fat, 3) Fruits and vegetables, and 4) Bakery. Renal function was based on microalbuminuria and glomerular filtration rate (GFR) estimated through CKD-EPI formula. Association between dietary patterns and renal function was investigated through mediation analysis.

Results

Participants mean age was 52±9 years, with 54% female. Dietary patterns found were: traditional (45.7%), fruits/vegetables (25.5%), bakery (24.4%), low sugar/low fat (4.3%). For men, the patterns “bakery” and “fruits and vegetables” had significant effects on GFR and microalbuminuria. The “fruits and vegetables” pattern had only indirect effect on both GFR and microalbuminuria. For women, the “bakery products” pattern presented total effect on GFR and microalbuminuria. The “fruits and vegetables” pattern had the same effect, except for also presenting direct effect on GFR without adjustment (Figure 1).

Conclusion

There is association between dietary patterns and renal function. The “bakery” diet seem to have negative effect on renal function. The “fruits and vegetables” pattern have association with renal function possible due to epidemiological reverse causality effect.

Funding

  • Government Support - Non-U.S.