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Abstract: TH-PO253

Factors Associated with Anemia in Nondialysis CKD

Session Information

Category: Anemia and Iron Metabolism

  • 202 Anemia and Iron Metabolism: Clinical

Authors

  • Zanetti, Lucas Albino, Faculdade das Américas, São Caetano do Sul, Brazil
  • Samorano, Alexandre Kaissar, Faculdade das Américas, São Caetano do Sul, Brazil
  • Kato, Thais Tiemi, Faculdade das Américas, São Caetano do Sul, Brazil
  • Canziani, Maria Eugenia F., Federal University of Sao Paulo, Sao Paulo, São PAULO, Brazil
  • Goes, Miguel Angelo, Federal University of Sao Paulo, Sao Paulo, São PAULO, Brazil
Background

Anemia is common among chronic kidney disease (CKD) patients with increased hospitalizations and mortality and is associated with inflammatory cytokines and iron status. Objective: To assess factors associated with anemia in nondialysis CKD patients.

Methods

We analyzed 100 nondialysis CKD outpatients no erythropoiesis-stimulating agent. Anemia was defined as hemoglobin (Hb) concentration <13.0 g/dL for men and <12.0 g/dL for women. Thus, 63 patients were in anemia group and 37 in non-anemia group. We performed analyzes of demographic data, CKD-EPI, Hb concentration, albumin, iron status, serum sFas, iPTH, inflammatory cytokines and erythropoietin (Epo) levels. We used correlations to all variables. We performed comparisons between two groups and multiple linear regression was used to determine the factors associated with Hb concentration when p<0.1.

Results

The primary causes of CKD were diabetes and hypertension followed by chronic glomerulonephritis. We observed in all patient together positive correlation between Hb and transferrin saturation (r=0.20, p=0.04), Hb and CKD-EPI (r=0.42, p<0.001), Hb and albumin (r=0.39, p=0.003). There was negative correlation between Hb and sFas (r=-0.50, p<0.001). We observed lower CKD-EPI (48+23, 27+10 mL/min; p=0.001), Hb (14.1+1.4, 10.9+1.6 g/dL; p<0.001) and serum Epo (14.2+9.5, 9.4+4.7 pg/mL; p=0.08) in anemia group. We found higher levels of sFas (3575+1109, 2533+1025 pg/mL; p<0.001), IFNg (7.1+5.9, 5.7+3.2 pg/mL; p=0.09) and iPTH (271+47.3, 110+47.8 pg/mL; p=0.003) in anemia group. Albumin (b = 3.518, 95%CI 1.059-3.873; p<0.001) and sFas (b = -0.252, 95%CI -0.852-0.17; p=0.001) were independently associated with Hb concentration.

Conclusion

This study shows that levels of albumin and sFas were associated with anemia in nondialysis CKD outpatients.