Kidney Week

Abstract: INFO13

Mayo Translational Polycystic Kidney Disease Center (MTPC)

Session Information

• Informational Posters
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category:

• No subcategory defined

Authors

• Kline, Timothy L., Mayo Clinic, Rochester, Minnesota, United States

Timothy L. Kline,

• Senum, Sarah R., Mayo Clinic, Rochester, Minnesota, United States

Sarah R. Senum,

• Wells, Harrison H., Mayo Clinic, Rochester, Minnesota, United States

Harrison H. Wells,

• Smith, Jessica M., Mayo Clinic, Rochester, Minnesota, United States

Jessica M. Smith,

• Sussman, Caroline R., Mayo Clinic, Rochester, Minnesota, United States

Caroline R. Sussman,

• Hu, Jinghua, Mayo Clinic, Rochester, Minnesota, United States

Jinghua Hu,

• Chebib, Fouad T., Mayo Clinic, Rochester, Minnesota, United States

Fouad T. Chebib,

• Irazabal, Maria V., Mayo Clinic, Rochester, Minnesota, United States

Maria V. Irazabal,

• Romero, Michael F., Mayo Clinic College of Medicine, Rochester, Minnesota, United States

Michael F. Romero,

• Erickson, Bradley J., Mayo Clinic, Rochester, Minnesota, United States

Bradley J. Erickson,

• Ekker, Stephen C., Mayo Clinic , Rochester, Minnesota, United States

Stephen C. Ekker,

• Harris, Peter C., Mayo Clinic, Rochester, Minnesota, United States

Peter C. Harris,

• Torres, Vicente E., Mayo Clinic, Rochester, Minnesota, United States

Vicente E. Torres,

Description

The overall goal of the NIDDK P30 funded, Mayo Translational PKD Center (MTPC) is to provide core facilities to support existing and stimulate new PKD research by Mayo and non-Mayo investigators. These services are designed to facilitate the translation of basic research breakthroughs into improvements in clinical practice through the implementation of clinical trials. The three MTPC Biomedical Research Cores are: Molecular Genetics and Biomarker, Model Systems, and Human Imaging, with the PKD Foundation ADPKD Mutation Database also closely associated with the MTPC. The Molecular Genetics and Biomarker Core characterizes PKD populations using focused and global next generation sequencing approaches to facilitate clinical trials, to aid genotype/phenotype studies and gene discovery, and to provide materials and information to catalyze understanding of disease pathogenesis. The Model Systems Core empowers PKD research through developing and facilitating access to PKD models in C. elegans, zebrafish and rodents, providing expertise for novel phenotypic characterization, including NMR imaging, and testing novel therapeutics. The Human Imaging Core provides accurate, reliable and automated (e.g. MIROS) analysis of imaging data and applies new and enhanced qualitative and quantitative methodologies (e.g. texture analysis) to measure disease progression and therapeutic outcomes in ADPKD. The ADPKD Mutation Database collates and evaluates the significance of >3300 variants in the PKD1 and PKD2 genes to aid diagnostics and categorization of patient populations. The Pilot and Feasibility Program funds four, 2-year research projects to attract new investigators into PKD research and to test new directions, and are open to Mayo and non-Mayo investigators, with the aim of developing a new generation of PKD researchers. The Scientific Enrichment Program provides an education and training dimension to the center to facilitate synergy among its members.

Funding

• NIDDK