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Abstract: TH-PO415

Serum Osteoprotegerin Level Is Positively Associated with Peripheral Artery Disease in Patients with Peritoneal Dialysis

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Lin, Wei-Chen, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
  • Hsu, Bang-Gee, Buddhist Tzu Chi General Hospital, Hualien, Not applicable, Taiwan
Background

Osteoprotegerin (OPG) levels may be a potential biomarker of complications and severity of cardiovascular disease. Peripheral arterial disease (PAD) is associated with an increased risk of death in peritoneal dialysis (PD) patients. Our aim was to evaluate the relationship between serum OPG levels and PAD by ankle-brachial index (ABI) among PD patients.

Methods

Fasting blood samples were obtained from 70 PD patients. The ABI values were measured using an ABI-form device (VaSera VS-1000). Serum OPG levels were measured using a commercial enzyme-linked immunosorbent assay kit. Left or right ABI values that were < 0.9 were included in the low ABI group.

Results

Among 70 PD patients, 13 patients (18.6%) were in the low ABI group. Compared with patients in the normal ABI group, patients in the low ABI group had higher prevalence of diabetes (p = 0.044), higher serum C reactive protein (CRP) (P < 0.001), and higher serum OPG level (P < 0.001), while lower serum creatinine level (P = 0.013) and peritoneal Kt/V (P = 0.048). According to the multivariate logistic regression analysis, OPG (Odds ratio [OR]: 1.027, 95% confidence interval [CI]: 1.010-1.045, P = 0.002) and CRP (each increase of 0.1 mg/dL, OR: 1.102, 95% CI: 1.006-1.207, P = 0.037) were the independent predictors of PAD in PD patients. The area under the receiver operating characteristic (ROC) curve (AUC) indicates the diagnostic power of OPG at predicting PAD of PD patients was 0.823 (95% CI: 0.714-0.904, P < 0.001).

Conclusion

In this study, serum OPG level was proved to be involved in the pathogenetic process of PAD in PD patients.