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Abstract: TH-PO414

Serum Osteopontin Level Is Positively Associated with Central Arterial Stiffness in Patients with Peritoneal Dialysis

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Lin, Wei-Chen, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
  • Hsu, Bang-Gee, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
Background

Osteopontin (OPN) is generally regarded as a proinflammatory and proatherogenic molecule and is associated with atherosclerosis. The aim of this study was to evaluate the relationship between serum OPN on central arterial stiffness by measuring of carotid-femoral pulse wave velocity (cfPWV) values in patients with peritoneal dialysis (PD).

Methods

Fasting blood samples were obtained from 70 PD participates in the study. Carotid-femoral pulse wave velocity was measured by a validated tonometry system. cfPWV values of > 10 m/s were used to define the high central arterial stiffness group, while values ≤ 10 m/s were regarded as the control group, according to the ESH-ESC 2013 guidelines. Serum OPN levels were measured using a commercial enzyme-linked immunosorbent assay kit.

Results

Twenty-two patients (31.4%) had high central arterial stiffness and were of older age (P = 0.001) and had longer PD vintage (P = 0.024), higher C-reactive protein (P = 0.005) and OPN levels (p < 0.001) compared to subjects with control group. Multivariate logistic regression analysis of the factors significantly associated with central arterial stiffness revealed that OPN (odds ratio: 1.044, 95% confidence interval: 1.020–1.069, P < 0.001) and PD vintage (odds ratio: 1.027, 95% confidence interval: 1.007–1.047, P = 0.009) were the independent predictors of central arterial stiffness in PD patients. Multivariate forward stepwise linear regression analysis also showed that OPN level (β = 0.477, adjusted R2 change = 0.269, P = 0.001) was positively associated with cfPWV values in PD patients.

Conclusion

In this study, serum OPN level was positively associated with cfPWV values in PD patients and was the independent predictors of central arterial stiffness in PD patients.