Kidney Week

Abstract: TH-PO311

A Retrospective Study on the Decline of Muscle Mass in Maintenance Hemodialysis Patients in China

Session Information

• Dialysis: Cost, Socioeconomics, Quality of Life
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Song, Yiqi, Division of Nephrology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

Yiqi Song,

• Zhang, Qian, Division of Nephrology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

Qian Zhang,

• Ni, Li, huashan hospital,Fudan University, Shanghai, China

Li Ni,

• Chen, Jing, Huashan Hospital, Shanghai, SHanghai, China

Jing Chen,

Background

Sarcopenia is characterized by age-related decline of skeletal muscle plus low muscle strength and/or physical performance. Studys have demonstrated that sarcopenia was associated with adverse health outcomes, such as disability, hospital admission, poorer quality of life and mortality. A high prevalence of sarcopenia is also observed in maintenance hemodialysis (MHD) patients, which need for further investigation. Hence, this study aimed to analyze the risk factors that affect the speed of muscle mass decline in MHD patients.

Methods

The retrospective study was performed in hemodialysis center of Huashan hospital, Fudan university in Shanghai, China. MHD patients suffered muscle mass loss in the past three years were eligible to participate in this study. Patients were divided into low speed group and high speed group according to the speed of muscle mass decline. Univariate linear regression analysis was conducted to assess the associations between muscle mass decline speed and the variables. These variables included age, gender, dialysis vintage, body mass index, normalized protein catabolic rate, serum levels of albumin, hsCRP, 25(OH)D, CO₂-CP. Variables with P≤0.20 were included in the multivariate logistic analysis.

Results

A total of 47 MHD patients were included in this study, of which 23 were male and 24 were female. Mean patient age was 59.30±12.49 years. The mean dialysis duration was 7.24±4.88 years. The low speed group showed shorter dialysis vintage, higher level of serum 25(OH)D and lower Log NT-proBNP,compared with the high speed gruop.There were no significant differences in albumin, prealbumin, cholesterol, nPCR, CO₂-CP, hsCRP, BMI, deltoid skin fold thickness, grip strength and daily steps. Multivariate linear regression analysis showed that dialysis vintage (β=0.309, P=0.017), 25 (OH) D(β=-0.370, P=0.004), Log NT-proBNP (β=0.339,P=0.011) were risk factors associated with muscle mass decline speed in MHD patients.

Conclusion

Risk factors associated with the muscle mass decline speed in maintenance hemodialysis patients include dialysis vintage, 25 (OH)D, and log NT-proBNP. Higher levels of 25 (OH) D contributes to the maintenance of muscle mass.