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Abstract: TH-PO373

Changes over Time in Outcomes of Incident Peritoneal Dialysis Patients in Southern China

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Peng, Yuan, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Yi, Chunyan, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Wu, Meiju, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Yu, Xueqing, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Yang, Xiao, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Background

The present study was to investigate the changes in outcomes of incident patients who stated peritoneal dialysis (PD) between 2006-2010 and 2011-2015 in Southern China.

Methods

In this single center retrospective cohort study, incident PD patients from January 1, 2005, to December 31, 2015 at the PD center of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China were enrolled. Collected baseline data include demographic characteristics and clinical outcomes. Patients initiated PD during 2006-2010 and 2011-2015 were followed-up until December 31, 2011 and December 31, 2016, respectively. The outcomes were compared between the two incident cohorts.

Results

A total of 2021 incident PD patients were enrolled, with mean age 47.2±15.2 years, 40.6% were female. Compared with the 2006–2010 cohort (n=1073), patients initiating PD during 2011-2015(n=948) were younger (46.2±14.8 vs 48.1±15.5 years, p=0.006), had similar baseline eGFR(5.81±2.41 vs. 5.81±2.89 ml/min/1.73m2, p=0.109) and comparable percentage of diabetes mellitus (24.9% vs 25.7%,p=0.682).The overall peritonitis rate between 2011 and 2015 was lower than 2006-2010 (0.157 vs. 0.160 per patient year, p=0.001). By the end of 1, 3 and 5 years, patients survival rates were 94%, 82% and 63% in 2006-2010 and 97%, 87% and 73% in 2010-2015, respectively (p<0.001); and technique survival rates were 98%, 92% and 85% in 2006-2010 and 98%, 90% and 80% in 2010-2015, respectively (p=0.204).After multivariable-adjusted, patients starting PD in 2011-2015 was associated with lower risk of all-cause mortality (HR 0.76, 95%CI 0.60-0.97, p=0.029).

Conclusion

Peritonitis episodes and patient survival on PD continues to improve, while technical survival remains unchanged. Patients initiating PD between 2010 and 2015 was associated with better patient survival.

Cumulative patient survival according to era of PD initiation

Funding

  • Government Support - Non-U.S.