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Abstract: TH-PO416

Relationship Between Hypomagnesemia and Abdominal Calcification Index in Peritoneal Dialysis Patients: A Cross-Sectional Study

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Harada, Kenji, Kokura memorial hospital, Kitakyusyu city, FUKUOKA, Japan
  • Kanai, Hidetoshi, Kokura Memorial Hospital, Kita Kyushu, Japan
  • Tanaka, Shigeru, Fukuoka Dental College, Fukuoka, Japan
Background

Several previous reports have reported that hypomagnesemia was associated with high mortality in hemodialysis (HD) patients. However, the influence of hypomagnesemia on the prognosis of peritoneal dialysis (PD) remains unclear. We investigated relationship between abdominal calcification index (ACI) and cardiovascular risk factors in PD patients.

Methods

A total of 184 PD patients were included in the current study. ACI was calculated calculated as average calcification area of consecutive 20 slices of abdominal aorta measured by abdominal plain CT (computerized tomography). We evaluated relationships between ACI and cardiovascular risk factors, including serum phospahte, serum calcium, whole parathyroid hormone, serum agnesium, lipid status, Hemoglobin A1c (HbA1c), blood pressure (BP), peritoneal function, echocardiographic findings.

Results

The overall, mean age was 64.9 years old, male/female was 132/52, average PD vintage was 12 months. Median value of magnesium was 1.92±0.3 mg/dl. We deviated participants into two groups; low magnesium (Mg<1.9) group and high magnesium (Mg≧2) group. Low magnesium group had a lower HbA1c and higher ACI. There was no difference in age, sex, ejection fraction, BP, peritoneal function, past history of cardiovascular disease between two groups. In the multiple regression analysis, hypomagnesemia was an independent predictor for high ACI (β=-2.73, P<0.007).

Conclusion

Hypomagnesemia at initiation of PD was strongly correlated with high ACI and its relationship did not change even after adjusting by plausible cardiovascular risk factors, hypomagnesemia was an independent predictor for high ACI. These results suggest that hypomagnesemia might be involved in calcification progression in PD patients.