Abstract: FR-PO470
Diabetic Fibrillosis, Not an Uncommon Entity: A Case Series
Session Information
- Diabetic Kidney Disease: Clinical - I
October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 602 Diabetic Kidney Disease: Clinical
Author
- Raju, Sree bhushan, NIMS, Hydrabad, India
Background
Diabetic Fibrillosis (DF) is a rare glomerular abnormality detected in electron microscopy as random nonbranching fibrillary deposits in mesangium. There are few case reports available related to this entity and we report a case series of this interesting association.
Methods
We reviewed all the cases of type 2 diabetic patients who underwent renal biopsy for various indications in last one year (April 2017 to march 2018) . Cases which were reported as DF in electron microscopy were collected. Clinical course, investigation reports and biopsy findings were analysed.
Results
DF was reported in 5 (3.7 %) out of 134 cases of diabetic nephropathy. The mean age was 55.6±.6 years (46-65). All five had both hypertension and diabetes. Mean duration of diabetes was 12± 2.7years. All five had increased serum creatinine with mean of 6.9±3.5 mg/dl. Three patients had nephrotic and two had subnephrotic range proteinuria (mean 3±1.3 g/day). Autoimmune and myeloma workup was negative. Light microscopy showed diabetic nephropathy class IV with arteriolar hyalinosis in all 5 cases. The Immunofluorescence and congo red stain was negative in all. GBM thickening is seen in all cases with mean thickness ranging from 426 to 714 nm. Random non branching fibrillary deposition is seen in mesangium of all cases. No spherular microparticles or tubuloreticular inclusions were seen.
Conclusion
diabetic fibrillosis is not an uncommon entity with a prevalence of 3.7 % in our case series. The clinical significance of this entity is yet to be determined. The observations made in this series needs to be elicited with a larger series of cases to know the impact on long term kidney function.