Abstract: TH-PO1032
Urinary Soluble CD163 Level Predicts Renal Prognosis of IgA Nephropathy
Session Information
- Glomerular Diseases: Clinical, Outcomes, Trials - I
October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1203 Glomerular Diseases: Clinical, Outcomes, and Trials
Author
- Tian, Jiong, Kidney Disease Center, the First Affiliated Hospital, College of Medicine,Zhejiang University, HANGZHOU, ZHEJIANG, China
Background
In IgA nephropathy (IgAN),crescent percentage was added to the make the new Oxford MESTC scores system recently. Macrophage is the most important inflammatory cell type in crescent and CD163 is a specific marker for M2c macrophage. Its soluble form (sCD163) is present in the bio-fluid in inflammation.sCD163 may serve as a biomarker for macrophage activation but its role in renal prognosis is unknown.
Methods
115 patients of IgAN were studied. Clinical parameters including blood pressure, urinary protein, creatinine and eGFR at renal biopsy and the last follow-up were recorded. The renal end point was defined as ESRD or the eGFR declined >50% or serum creatinine doubled during the follow up. The serum and urinary level of sCD163 were determined by ELISA.
Results
The cohort were divided into three groups according to the crescent percentage. Urinary sCD163 in group C2 (crescents in>25% of glomeruli) were significantly elevated compared to that in group C1 (crescents in <25% of glomeruli) and group C0 (no crescent). Urinary sCD163 level was negatively correlated with eGFR and positively correlated with serum creatinean and proteinuria. Urinary sCD163 level was associated with M,E,S and C scores. There was a significantly positive correlation between urine urinary sCD163 level and the percentage of crescents.Renal end points developed in 12 patients during the 42.6±7.4 months of follow-up.Most importantly,our results showed that increased urinary sCD163 level was significantly associated with poor renal outcome.
Conclusion
The level of urinary sCD163 was closely related to clinical and pathological features in IgAN and it can serve as a non-invasive biomarker to reflect the severity of IgAN. An increased urinary sCD163 level was related with poor renal outcome in patients with IgA nephropathy.