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Abstract: FR-PO452

Serum Soluble CD163 Associates with Estimated GFR and History of Ischemic Heart Disease in Adults with Diabetes

Session Information

Category: Diabetic Kidney Disease

  • 602 Diabetic Kidney Disease: Clinical

Authors

  • Griffin, Tomas P., Saolta University Health Care Group (SUHCG), Galway University Hospitals, Galway, Ireland
  • Dempsey, Daniel, Trinity College Dublin, Dublin, Ireland
  • Morrin, Aisling, Trinity College Dublin, Dublin, Ireland
  • Islam, Md Nahidul, at CÚRAM SFI Research Centre, School of Medicine, National University of Ireland Galway (NUIG), Galway, Ireland
  • Moran, Sarah Margaret, Trinity College Dublin, Dublin, Ireland
  • O'Shea, Paula Mary/m, Saolta University Health Care Group (SUHCG), Galway University Hospitals, Galway, Ireland
  • Wyse, Jason, Trinity College Dublin, Dublin, Ireland
  • Little, Mark Alan, Trinity College Dublin, Dublin, Ireland
  • Griffin, Matthew D., at CÚRAM SFI Research Centre, School of Medicine, National University of Ireland Galway (NUIG), Galway, Ireland
Background

CD163 is a scavenger receptor for haptoglobin-haemoglobin complexes that is expressed by monocytes/macrophages and undergoes ectodomain shedding into blood as soluble CD163(sCD163) in an inflammatory milieu. Activation of monocytes/macrophages is implicated not only in the pathophysiology of diabetes but also in the development of glomerular injury in diabetic kidney disease. The aim of this study was to determine the relationships between serum sCD163 and clinical/biochemical parameters in a cohort of diabetic patients with a broad range of renal functional parameters.

Methods

A total of 201 adults with diabetes (eGFR[CKD-EPI] range 10-143mL/min/1.73m2) were recruited to a prospective cohort study. Subjects had serum collected at 1-4 timepoints(stored at -80oC). Clinical, anthropometric and biochemical data were recorded at each timepoint. Serum sCD163 concentration was quantified using R&D ELISA(DY1607). To analyse the longitudinal relationships between relevant clinical/laboratory parameters and sCD163, a linear mixed model was fitted in R.

Results

Of 23 parameters included in the model, there were significant associations between serum sCD163 and eGFR, ALT, diuretic use and history of ischaemic heart disease(IHD). The highest value coefficients of association with serum sCD163 were for eGFR(negative) and IHD(positive) (Fig 1). Parameters for which no significant association was observed included BMI, HbA1c, urine ACR and lipids.

Conclusion

In adults with diabetes, serum sCD163 associated most closely with eGFR and IHD. Thus, variation in serum sCD163 among adult diabetic patients may reflect, in part, the role of monocyte/macrophage activation in renal and cardiovascular complications of diabetes.

Funding

  • Government Support - Non-U.S.