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Abstract: FR-PO741

Effects of Glucose-Containing Dialysate During Hemodialysis

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Yoo, Mijung, Inje University Haeundae Paik Hospital, ULSAN, Korea (the Republic of)
  • Kim, Yang Wook, Haeundae Paik Hospital, inje university, BUSAN, Korea (the Republic of)
  • Park, Bongsoo, Inje University, Haeundae Paik Hospital, BUSAN, Korea (the Republic of)
  • Park, Sihyung, Inje University, Haeundae Paik Hospital, BUSAN, Korea (the Republic of)
  • Lee, Yoo jin, Haeundae Paik Hospital, BUSAN, Korea (the Republic of)
Background

When hemodialysis is performed using glucose-free dialysate, glucose is released into the dialyzer and hypoglycemia may occur. Repeated occurrence of hypoglycemia increases the risk of cognitive decline and reduces the quality of life of patients. In this study, we aimed to compare the incidence of hypoglycemia and biochemical changes in patients with hemodialysis using glucose-containing dialysate and glucose-free dialysate.

Methods

All patients were dialyzed with glucose-free dialysate and changed to glucose-containing dialysate. We measured the levels of albumin, BUN, creatinine, total cholesterol, triglyceride, C-reactive protein, calcium, phosphorus, SPKt/V and URR 3 months before and after dialysate change. Two hours after the start of dialysis, blood glucose level was measured. When the blood glucose level was less than 90 mg/dl, 100 ml of 50% dextrose fluid was administered and the number of times was recorded.

Results

A total of 53 patients participated in the study. When comparing before and after dialysis solution change, no statistically significant differences were found in albumin(g/dl)(3.53±0.36 vs 3.54±0.34; p-value 0.87), BUN(mg/dl)(60.02±19.07 vs 60.46±16.26; p-value 0.87), creatinine(mg/dl)(9.42±2.66 vs 9.36±2.68; p-value 0.95), total cholesterol(mg/dl)(148.83±33.39 vs 147.19±30.44; p-value 0.56), triglyceride(mg/dl)(113.57±75.55 vs 117.34±78.40; p-value 0.65), C-reactive protein(mg/dl)(0.38±0.63 vs 0.37±0.60; p-value0.61), calcium(mg/dl)(9.63±9.31 vs 8.35±0.58; p-value 0.61), phosphorus(mg/dl)(4.77±1.43 vs 5.03±1.31; p-value 0.18), SPKt/V(1.57±0.23 vs 1.59±0.24; p-value 0.40) and URR(71.74±10.36 vs 73.26±5.01; p-value 0.49). The mean number of dextrose fluid administration was statistically significant(0.16±0.27 vs 0.03±0.08; p-value 0.00).

Conclusion

Hyperglycemia is known to increase the production of free radials and to induce oxidative stress. However, in our study, with glucose-containing dialysate, the deterioration of inflammatory markers associated with oxidative stress was not observed, the incidence of hypoglycemia was reduced, and the dialysis efficiency remained similar. It is believed that the use of glucose-containing dialysate will be more beneficial to the patient.