Kidney Week

Abstract: TH-PO163

A Prospective Observational Study Comparing Bone Loss in Renal Transplant and Dialysis Patients

Session Information

• Transplantation: Cardiovascular and Metabolic Diseases
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 1802 Transplantation: Clinical

Authors

• Hassan, Waleed, University of Kentucky, Lexington, Kentucky, United States

Waleed Hassan,

• Yaseen, Maria, University of Kentucky, Lexington, Kentucky, United States

Maria Yaseen,

• Ashqar, Hasan, University of Kentucky, Lexington, Kentucky, United States

Hasan Ashqar,

• Mohamed, Amr El-Husseini, University of Kentucky, Lexington, Kentucky, United States

Amr El-Husseini Mohamed,

• Lowry, Conor, University of Kentucky, Lexington, Kentucky, United States

Conor Lowry,

• Gedaly, Roberto, University of Kentucky, Lexington, Kentucky, United States

Roberto Gedaly,

• Davenport, Daniel, University of Kentucky, Lexington, Kentucky, United States

Daniel Davenport,

• Lima, Florence, University of Kentucky, Lexington, Kentucky, United States

Florence Lima,

• Malluche, Hartmut H., University of Kentucky, Lexington, Kentucky, United States

Hartmut H. Malluche,

Background

Bone loss has been reported with chronic dialysis and after renal transplantation. This study compared the differences in longitudinal changes in BMD between dialysis and transplant patients using quantitative computed tomography (QCT).

Methods

Total hip BMD was assessed using QCT in 29 renal transplant recipients at the time of transplantation, at 6 months (n=25), and at 12 months (n=19). In addition 50 dialysis patients of similar gender, age, race, dialysis vintage, diabetes, non-smoking status, coronary artery disease, and exercise were studied. BMD at baseline and after 12 months was compared between the two groups.

Results

In transplant patients, total hip BMD by QCT decreased from a mean of 0.88 g/mm³ at time of transplantation to 0.83 g/mm³ at 6 months after transplant, then stabilized at 0.83 g/mm³ at 12 months for an average loss of 0.05 ± SE 0.02 g/mm³ (fig. 1). While the average dialysis patient lost 0.02 ± SE 0.01 g/mm³ of BMD at the hip over 12 months (p= 0.07, Figure 2). The average bone loss was higher for transplant patients with normal baseline BMD compared to patients with low BMD (Normal: -0.05 g/mm3; Low: -0.02, p=0.314).

Conclusion

Significant bone loss occurs in renal transplant recipients during the first 6 months then stabilized at 12 months. This bone loss is more than what is observed in matched dialysis patients. Normal BMD is still of concern because bone loss may be higher compared to patients with low BMD.