ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Abstract: SA-PO1062

Effect of Intra-Dialysis Nutrients Admixture vs Conventional Intra-Dialysis Parenteral Nutrition on Nutrition Status and Inflammation in Malnourished Hemodialysis Patients

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1302 Health Maintenance, Nutrition, and Metabolism: Clinical

Authors

  • Supasyndh, Ouppatham, Phramongkutklao hospital, Bangkok, Thailand
  • Boonkarn, Wongsakorn, Phramongkutklao hospital, Bangkok, Thailand
  • Tangwonglert, Theerasak, Phramongkutklao hospital, Bangkok, Thailand
  • Tasanavipas, Pamila, Phramongkutklao hospital, Bangkok, Thailand
  • Chaiprasert, Amnart, Phramongkutklao hospital, Bangkok, Thailand
  • Nata, Naowanit, Phramongkutklao hospital, Bangkok, Thailand
  • Satirapoj, Bancha, Phramongkutklao hospital, Bangkok, Thailand
Background

Protein/caloric malnutrition and inflammation is a major problem in long-term hemodialysis patients. Total nutrients admixture containing 80% olive oil-base intravenous lipid emulsions and low proportion of polyunsaturated fatty acids may offer several advantages such as a reduction of oxidative and inflammatory effects in end stage renal disease (ESRD).

Methods

The study was a randomized controlled trial; patients with malnourished ESRD on hemodialysis were randomly assigned into an admixture-IDPN group (n=13) and a conventional-IDPN group (n=13). Nutritional assessment, and inflammatory markers including high sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured at baseline and 4 weeks following intervention.

Results

At the end of 4-week, nutritional parameters including serum albumin (0.41±0.18 vs 0.16±0.22, P=0.004), pre-albumin (7.88±4.6 vs. 2.01±2.63. P=0.001) and urea reduction ratio (2.92±0.76 vs 0.92±2.78, P=0.026) in the admixture-IDPN group have a significantly greater improvement than the conventional-IDPN group. The decline in serum IL-6 levels was -13.9 pg/mL larger among admixture-IDPN vs conventional-IDPN group (95% CI -20.41 to -7.4 pg/mL). The admixture-IDPN group had also higher absolute lymphocyte counts and lower hs-CRP levels after treatment, but there were no significant changes in the conventional-IDPN group. There were no statistically significant differences between the two groups in the risk of electrolytes abnormalities and adverse events.

Conclusion

Malnourished ESRD patients on dialysis receiving olive oil-base lipid emulsions and low polyunsaturated fatty acids IDPN resulted in modest improvements in nutritional status and inflammatory cytokines.