Kidney Week

Abstract: FR-PO692

Time-Course Changes in the Levels of Biomarkers in Peritoneal Dialysis Effluent Among Patients Using New Neutral Fluids

Session Information

• Dialysis: Peritoneal Dialysis - II
  October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 703 Dialysis: Peritoneal Dialysis

Authors

• Terashima, Risa, The Jikei University School of Medicine, Tokyo, Japan

Risa Terashima,

• Tanno, Yudo, The Jikei University School of Medicine, Tokyo, Japan

Yudo Tanno,

• Matsuo, Nanae, The Jikei University School of Medicine, Tokyo, Japan

Nanae Matsuo,

• Maruyama, Yukio, The Jikei University School of Medicine, Tokyo, Japan

Yukio Maruyama,

• Ohkido, Ichiro, The Jikei University School of Medicine, Tokyo, Japan

Ichiro Ohkido,

• Yokoyama, Keitaro, The Jikei University School of Medicine, Tokyo, Japan

Keitaro Yokoyama,

• Yokoo, Takashi, The Jikei University School of Medicine, Tokyo, Japan

Takashi Yokoo,

Background

Recently, new neutral peritoneal dialysis fluid (PDF) contained bicarbonate 25mEq/L and lactate 10mEq/L (Bic/Lac PDF), instead of lactate 40mEq/L contained neutral fluid (Lac PDF), was available in Japan. The levels of biomarkers in PD effluents are used as the indexes of peritoneal deterioration associated with PD. However, there are few reports evaluating time-course changes in biomarker levels according to dwell time using Bic/Lac PDF.

Methods

Six stable PD patients were included (72±6 y/o, male 83%, PD duration 52.8±32.8 months). We compared the levels of CA125, IL-6, FDP, VEGF, and TNF-α in PD effluents between Bic/Lac PDF and Lac PDF after a dwell time of 2, 4, 6, and 8 hours.

Results

The levels of CA125 and IL-6 after the dwell time of 2, 4, 6, and 8 hours were as follows; CA125: Bic/Lac PDF, 13.2±6.5, 21.3±10.9, 26.8±14.2, and 33.6±19.1 U/mL; Lac PDF, 10.5±3.6, 16.6±5.6, 21.5±8.0, and 27.4±10.5 U/mL, and IL-6: Bic/Lac PDF, 10.1±7.8, 16.9±9.0, 23.4±10.3 and 33.2±11.9 pg/mL; Lac PDF, 12.1±6.9, 21.1±11.6, 29.4±16.2, and 43.2±23.6 pg/mL, respectively. The levels of FDP also showed increasing trends over time. The levels of VEGF and TNF-α in some samples were below the detection limits up to a dwell time of 6 hours.

Conclusion

The levels of biomarkers in PD effluents are greatly affected by PDF dwell time. Time-course changes in the levels of biomarkers are similar between two PDF.

Funding

• Commercial Support – Baxter Healthcare