Abstract: TH-PO1011
Membranous Nephropathy at Diagnosis and Follow-Up: Comparison Between Elderly and Young Patients
Session Information
- Glomerular Diseases: Clinical, Outcomes, Trials - I
October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1203 Glomerular Diseases: Clinical, Outcomes, and Trials
Authors
- Brandão, Renata Paula martins, University of São Paulo, São Paulo, Brazil
- Dias, Cristiane B., University of São Paulo, São Paulo, Brazil
- Jorge, Lectícia, University of São Paulo, São Paulo, Brazil
- Malheiros, Denise M., University of São Paulo, São Paulo, Brazil
- Woronik, Viktoria, University of São Paulo, São Paulo, Brazil
Background
This study aims to evaluate the epidemiological profile between elderly and young patients with Membranous Nephropathy (MN) diagnosed in a single center.
Methods
This was a retrospective cohort study from 1999 to 2017, where clinical, epidemiological, laboratory and histological data of patients with MN accompanied by the Nephrology Department of the Hospital das Clinicas de São Paulo were evaluated. The only exclusion criterion was to have a diagnosis of Systemic Lupus Erythematosus at the time of the renal biopsy.
Results
In these period 219 patients had renal biopsy proving MN, presenting a mean age of 45.3 ± 15.7 years and 53.8% of women. Laboratory data at diagnosis were: serum creatinine median of 1.0 (0.8-1.7) mg/dl; median proteinuria of 6.0 (3.0-8.8) g/day and serum albumin median of 1.8 (1.2-2.5) g/dL. There were 48.4% of patients with hypertension and 35.6% with hematuria at diagnosis. A total of 44 (20%) patients were elderly at diagnosis and comparation with the young patients are in table 1. . Forty patients (18.2%) presented secondary causes, being infectious causes in 18, with hepatitis B in 4 patients; autoimmune causes in 11, with rheumatoid arthritis in 3; and cancer in 11.
Conclusion
MN showed a different epidemiological profile among young and elderly patients, with a predominance of men, hypertension, and increased serum initial creatinine in the latter group. The secondary forms corresponded to less than 20% in these cases, predominating the infectious and autoimmune etiologies.
Comparison between elderly and young patients with MN
| Elderly (≥ 60 years) n=44 | Young (<60 years) n=175 | p | |
| Male (n/%) | 28/63.6 | 73/41.7 | <0.05 |
| Hematuria (n/%) | 19/43.1 | 59/33.7 | ns |
| Proteinuria (g/day) -median (quartiles) | 5.3 (3.2-8.0) | 6.0 (2.9-9.2) | ns |
| Initial Serum creatinine (mg/dL) - median (quartiles) | 1.3 (1.0-2.3) | 1.0 (0.7-1.4) | <0.05 |
| Arterial hypertension (n/%) | 31/70.4 | 75/42.8 | <0.05 |
| Infectious etiology (n) | 3 | 15 | ns |
| Autoimmune etiology (n) | 2 | 9 | ns |
| Cancer etiology (n) | 4 | 7 | ns |
| Renal replacement therapy (n/%) | 5/11.3 | 8/4.5 | <0.05 |
| Death (n) | 0 | 4 |
ns- not significant