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Abstract: FR-OR084

Nephrotic Syndrome Is Significantly Associated with Increased Risk of Ischemic Stroke

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials


  • Wu, Ming-Ju, Taichung Veterans General Hospital, Taichung, Taiwan
  • Yu, Tung-Min, Taichung Veterans General Hospital, Taichung, Taiwan

Evidence on the risk of ischemic stroke in patients with nephrotic syndrome is scarce.


We conducted a retrospective nationwide cohort study by analyzing the registry data of the National Health Insurance Research Database in Taiwan. Adult patients who were aged ranged 18 to 110 years and had received a diagnosis of nephrotic syndrome were included in the nephrotic syndrome cohort. For each patient with nephrotic syndrome, the corresponding controls were selected 1:4 on the basis of matched age, sex, Charlson comorbidity index, and index date to evaluate the risk of stroke, especially the ischemic stroke.


The first three-year incidence rates of ischemic stroke were 25% and 15.9% in 3496 patients with nephrotic syndrome and 13984 comparison control cohorts, respectively. Overall, 9% patients with nephrotic syndrome developed ischemic stroke in 9.1±2.9 years follow-up period. A higher risk of stroke was observed in patients with nephrotic syndrome than in controls, adjusted hazard ratio (aHR) 1.37; 95% confidence interval (CI) 1.21-1.54, p<0.001. Regarding the risk of different stroke subtypes, including ischemic stroke and hemorrhagic stroke, the aHR for ischemic stroke was 1.38 (95% CI 1.21-1.57, p<0.001) and that for hemorrhagic stroke was 1.26 (95% CI 0.84-1.88, p=0.266) in patients with nephrotic syndrome compared with controls, after adjustment for age, sex, and comorbidities.


This study provides first significant evidence that patients with nephrotic syndrome had an increased risk of ischemic stroke.