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Abstract: TH-PO202

Association Between Serum Phosphorus level and Decline of Glomerular Filtration Rate in Heathy Individuals

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical


  • Wang, Mengjing, Huashan hospital, Fudan University, Shanghai, China
  • Ni, Li, huashan hospital,Fudan University, Shanghai, China
  • Zhang, Minmin, Huashan Hospital, Fudan Univerisy, Shanghai, China
  • Zhang, Jiaying, Fudan University, Shanghai, China
  • Ye, Guoxin, Division of Nephrology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  • Zhang, Weichen, Huashan Hospital, Shanghai, China
  • Chen, Weisheng, Huashan Hospital, Shanghai, China
  • Wang, Xiaofeng, Fudan University, Shanghai, China
  • Chen, Jing, Huashan Hospital,Fudan University, Shanghai, China

High serum phosphorus levels are strongly and independently associated with a more rapid decline of renal function in patients with advanced chronic kidney disease (CKD). We hypothesized that phosphorus was also associated with decline of Glomerular Filtration Rate (GFR) in heathy individuals.


We identified 1,340 healthy individuals with measured serum creatinine from the Rugao aging cohort over the period of Nov 2014 (baseline) to Nov 2017 (2nd follow-up). The association of phosphorus at the 2nd follow-up (Nov 2017), which was not measured at the baseline, with decrease of GFR between baseline and 2nd follow-up was examined using logistic models with adjustment for baseline demographics characteristics and laboratory variables.


The mean age (mean±SD) of the cohort was 75±4 years old and included 55% females, 7% diabetics, and 44% hypertension. Mean GFR estimated by CKD-EPI equation at baseline and the 2nd follow-up was 88.0 (±10) and 85.9 (±12) ml/min/1.73m2, respectively, with an average of 2 ml/min/1.73m2 decrease across the 3 years. Mean serum phosphorus level was 1.17(±0.16) mmol/l. Serum phosphorus was not associated with GFR at the baseline (P=0.1) or at the 2nd follow up (P=0.5). However, each 1-mmol/l increase in phosphorus concentrations was associated with approximately 3-fold increased risk for rapid GFR decline (defined as at least 4.5ml/min/1.73m2 decrease during the 3 years) after adjusted for age, gender, smoking, hypertension, cardiovascular disease, BMI, Low-density lipoprotein, triglyceride, albumin, and baseline GFR (OR 3.1, 95%CI 1.3-7.2, P = 0.01).


Higher phosphorus levels are associated with GFR decline in heathy individuals. Further studies are needed to validate this finding.