Kidney Week

Abstract: TH-PO202

Association Between Serum Phosphorus level and Decline of Glomerular Filtration Rate in Heathy Individuals

Session Information

• Bone and Mineral Metabolism: Clinical - I
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Bone and Mineral Metabolism

• 402 Bone and Mineral Metabolism: Clinical

Authors

• Wang, Mengjing, Huashan hospital, Fudan University, Shanghai, China

Mengjing Wang,

• Ni, Li, huashan hospital,Fudan University, Shanghai, China

Li Ni,

• Zhang, Minmin, Huashan Hospital, Fudan Univerisy, Shanghai, China

Minmin Zhang,

• Zhang, Jiaying, Fudan University, Shanghai, China

Jiaying Zhang,

• Ye, Guoxin, Division of Nephrology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

Guoxin Ye,

• Zhang, Weichen, Huashan Hospital, Shanghai, China

Weichen Zhang,

• Chen, Weisheng, Huashan Hospital, Shanghai, China

Weisheng Chen,

• Wang, Xiaofeng, Fudan University, Shanghai, China

Xiaofeng Wang,

• Chen, Jing, Huashan Hospital,Fudan University, Shanghai, China

Jing Chen,

Background

High serum phosphorus levels are strongly and independently associated with a more rapid decline of renal function in patients with advanced chronic kidney disease (CKD). We hypothesized that phosphorus was also associated with decline of Glomerular Filtration Rate (GFR) in heathy individuals.

Methods

We identified 1,340 healthy individuals with measured serum creatinine from the Rugao aging cohort over the period of Nov 2014 (baseline) to Nov 2017 (2^nd follow-up). The association of phosphorus at the 2^nd follow-up (Nov 2017), which was not measured at the baseline, with decrease of GFR between baseline and 2^nd follow-up was examined using logistic models with adjustment for baseline demographics characteristics and laboratory variables.

Results

The mean age (mean±SD) of the cohort was 75±4 years old and included 55% females, 7% diabetics, and 44% hypertension. Mean GFR estimated by CKD-EPI equation at baseline and the 2^nd follow-up was 88.0 (±10) and 85.9 (±12) ml/min/1.73m², respectively, with an average of 2 ml/min/1.73m² decrease across the 3 years. Mean serum phosphorus level was 1.17(±0.16) mmol/l. Serum phosphorus was not associated with GFR at the baseline (P=0.1) or at the 2^nd follow up (P=0.5). However, each 1-mmol/l increase in phosphorus concentrations was associated with approximately 3-fold increased risk for rapid GFR decline (defined as at least 4.5ml/min/1.73m² decrease during the 3 years) after adjusted for age, gender, smoking, hypertension, cardiovascular disease, BMI, Low-density lipoprotein, triglyceride, albumin, and baseline GFR (OR 3.1, 95%CI 1.3-7.2, P = 0.01).

Conclusion

Higher phosphorus levels are associated with GFR decline in heathy individuals. Further studies are needed to validate this finding.