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Abstract: FR-PO542

The Effect of Intradialytic and Home-Based Exercise on Physical Function and Quality of Life in Hemodialysis Patients

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1302 Health Maintenance, Nutrition, and Metabolism: Clinical


  • Burrows, Brett, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States
  • Perez, Luis M., University of Illinois at Urbana-Champaign, Urbana, Illinois, United States
  • Chan, Lauren, Illinois State University, Normal, Illinois, United States
  • Harris, Alana Pauline, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States
  • Barnes, Jennifer L., Illinois State University, Normal, Illinois, United States
  • Wilund, Ken, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States

It’s well established that hemodialysis (HD) patients are less active and have greater muscle atrophy compared to healthy people. Previous research has associated lack of physical activity with reduced physical function (PF) and quality of life (QOL) and increased mortality. Preceding research also states that HD patients’ QOL may be negatively influenced by significant increases in intradialytic weight gain thus increasing the likelihood of a hypotensive event. HD patient’s specifically cite sleep problems and fatigue as negative effects of hemodialysis on QOL. The aim of this study was to determine the effect of a 6-month physical exercise program on HD patients’ PF and QOL.


HD patients (n=22) were enrolled in a larger volume control (VC) pilot trial with assessments at baseline (BL) and 6-months (6m). Nine HD patients were randomized into a volume control and exercise group (VCE). During regularly scheduled HD treatments, over the 6-month trial, VCE performed thrice weekly moderate intensity, progressive intradialytic cycling for 15-30 min per session. Additionally, VCE was given a progressive individualized home exercise prescription that consisted of total body resistance exercises and balance exercises, which the HD patients were asked to complete twice a week. Thera-bands of various resistance were given to perform the exercises at home. Before randomization, BL assessments were taken including; BP, short physical performance battery (SPPB), and self-reported Kidney Disease Quality of Life (KDQoL).


SPPB total score did not improve BL to 6m between groups (VCE 9.4 to 10.1, VC 8.5 to 8.9; p=.71). The symptoms and sleep subsets, of the KDQoL, were significantly different between groups from BL to 6m (symptoms: VCE 73.2 to 85.0, VC 71.1 to 67.1; p=0.02, sleep: VCE 60.8 to 71.4, VC 58.5 to 50.9; p=0.02). Fatigue, part of the symptoms subset, was found to be reduced in VCE from BL to 6m (VCE 54.2 to 75.0, VC 51.7 to 40.0; p=0.05).


Despite no improvement in the SPPB between groups, specific QOL parameters such as sleep and fatigue improved significantly. These findings suggest novel benefits in QOL from an intradialytic cycling and home-based exercise program in HD patients.


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