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Abstract: INFO15

Mayo Clinic O’Brien Urology Research Center: Improving Stone Disease Treatment by Accurate Phenotyping and Risk Stratification

Session Information

  • Informational Posters
    October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM


  • No subcategory defined


  • Lieske, John C., Mayo Clinic, Rochester, Minnesota, United States
  • Rule, Andrew D., Mayo Clinic, Rochester, Minnesota, United States
  • Romero, Michael F., Mayo Clinic College of Medicine, Rochester, Minnesota, United States
  • Haley, William E., Mayo Clinic, Rochester, Minnesota, United States
  • Mccollough, Cynthia H., Mayo Clinic, Rochester, Minnesota, United States
  • Enders, Felicity T., Mayo Clinic, Rochester, Minnesota, United States

The Mayo Clinic O’Brien Urology Research Center (U54 DK10027) addresses critical unanswered questions in urinary stone disease research. The overall goals Center are to define the pathogenesis of nephrolithiasis and develop new diagnostic techniques in order to improve treatment and prevention strategies.

Important and timely aims of this Urology O'Brien Center include:
1) Develop and validate a comprehensive low-dose stone-characterization exam using clinical dual-energy CT techniques in order to predict stone fragility, and to develop new CT methods capable of detecting the earliest possible precursor lesions.
2) Determine factors that produce NL precursor lesions including Randall's plaques and tubular plugs.
3) Determine the role of infection/microbiome in urinary stone disease
4) Define mechanisms of stone growth and dissolution
5) Define specific factors that increase the risk of kidney stones and their recurrence, and develop clinical prediction tools to help clinicians identify high-risk patients.
6) Define environmental and genetic factors that influence oxalate transport and crystallization in a novel high throughput Drosophila model

Other activities of the center include:
1) CT Imaging Core
2) Urinary Phenotyping Core
3) Biostatistics/Epidemiology Core
4) A vigorous Pilot and Feasibility Program
5) Education enrichment program
6) Funded Summer undergraduate and medical student research program (R25-DK101405)

The Center brings together a multidisciplinary group of experienced clinicians and basic scientists to conduct translational research. Investigators are located at Mayo Clinic Rochester, Mayo Clinic Florida, Indiana University, and the University of Illinois. Key resources for the Center include the Mayo Clinic CT Clinical Innovation Center (CTCIC); the Rochester Epidemiology Project; the University of Illinois Roy J. Carver Biotechnology Center; investigators with expertise in genetics, geology, microbiology, proteomics and transport physiology; and large patient volumes.

Center investigators welcome opportunities for collaboration with other investigators as well as inquiries from students interested in urinary stone disease research. Contact for questions and more information.