Abstract: TH-PO1168
Short-Term Medium-Chain Triglycerides Supplementation on the Nutritional Status and Muscle Strength of Patients on Chronic Dialysis
Session Information
- Late-Breaking Clinical Trials Posters
October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- No subcategory defined
Authors
- Wu, Vincent, National Taiwan University Hospital, Taipei, Taiwan
- Chang, Chih-Hsiang, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Background
One of the major risk factors for cardiovascular disease is lipid abnormalities among hemodialysis patients. We prospectively evaluated the effects of medium chain triglycerides (MCT) supplementation on the nutritional status, muscle strength and anthropometrics of patients on chronic dialysis.
Methods
This study was randomized, double-blind comparison of placebo and active treatment for dialysis patients with MCT . In this full scale of the evaluation study, chronic dialysis patients who have malnutrition (serum albumin less than <3.8 g/DL) and did not have the active infection disease were included. Dietary supply with MCT and by daily dietary record review, we estimated the amount of dietary components in participants. Patients were supplied with the powder of MCT, 9.1g, (100kcal) daily while the control group received start (100 kcal) daily. The biochemical data, nutritional status, muscle power and anthropometrics were evaluated at baseline and 4 months later.
Results
Totally 84 patients (male, 43.8%; mean age, 62.7 years) of chronic dialysis with malnutrition (albumin 3.42± 0.32 g/dL) were included. Forty-two patients received MCT treatment (100 kcal daily) and another fourth-two patients received starch 100 kcal daily. After MCT treatment, the SGA 7-point nutritional score (5.22± 1.53 to 6.19 ± 1.36, p=0.001) and the estimated carbohydrate amount (127.7± 69.8 to 165.9± 42.5g, p=0.004) augmented. Additionally, the hand-grip strength (18.0± 6.8 to 19.2± 7.5kg, p =0.048) as well as the middle arm circumference (25.4 ± 2.72 to 26.9 ± 3.7 cm, p= 0.025) improved. However the patients received starch supplement did not improve muscle power or nutritional score.
Conclusion
In chronic dialysis patients with malnutrition, short- term daily oral MCT supply could improve the nutritional status in term of nutritional score and carbohydrate amount. It will contribute to the positive effect of muscle thickness and muscle power.